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Lyme Disease Bacterial Protein Urine Test

Massachusetts rates for HCPCS 0316U

Tests for Lyme disease by looking directly for OspA, a protein made by the Borrelia burgdorferi bacterium, in a urine sample, and reports whether it is found. Unlike most Lyme testing, it detects a protein made by the bacterium itself rather than the antibodies your immune system makes against it or the bacterium's genetic material.

Rates data updated July 2026.

Facilitymedian $35 · 10th–90th $13$790%10%20%10th90th$35Professionalmedian $19 · 10th–90th $11$370%20%40%10th90th$19$10.0$50.0$200.0$1.0K$5.0K$20.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$13.18
Median
$41.69
Typical High
$60.26
Aetna
Setting
Professional
Modifier
Global
Typical Low
$12.30
Median
$13.18
Typical High
$15.14
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$89.13
Median
$89.13
Typical High
$89.13
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$8.91
Median
$11.22
Typical High
$28.18
Cigna
Setting
Facility
Modifier
Global
Typical Low
$12.59
Median
$14.45
Typical High
$30.20
Cigna
Setting
Professional
Modifier
Global
Typical Low
$21.38
Median
$22.91
Typical High
$28.18
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$31.62
Median
$4,897.79
Typical High
$9,772.37
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$26.92
Median
$26.92
Typical High
$31.62
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$18.62
Median
$18.62
Typical High
$39.81
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$89.13
Median
$89.13
Typical High
$89.13
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$8.91
Median
$11.22
Typical High
$28.18
United
Setting
Facility
Modifier
Global
Typical Low
$11.22
Median
$18.62
Typical High
$22.39
United
Setting
Professional
Modifier
Global
Typical Low
$11.22
Median
$18.62
Typical High
$53.70