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Large Multi-Gene Tumor Sequencing Panel

Nationwide rates for HCPCS 81455

This laboratory service analyzes a large panel of genes from a tumor or blood sample to look for genetic changes that can help guide cancer diagnosis and treatment decisions. It examines many genes at once using next-generation sequencing technology, offering a broader look than smaller, more targeted gene panels. Results can help identify mutations that inform prognosis or point toward targeted therapies.

Rates data updated July 2026.

Facilitymedian $3,715 · 10th–90th $1,738$10,9650%10%10th90th$3,715Professionalmedian $2,344 · 10th–90th $1,175$5,0120%20%10th90th$2,344$2.0$20.0$200.0$2.0K$20.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$1,778.28
Median
$3,890.45
Typical High
$9,120.11
Aetna
Setting
Professional
Modifier
Global
Typical Low
$724.44
Median
$2,344.23
Typical High
$4,570.88
BCBS
Setting
Facility
Modifier
Global
Typical Low
$2,570.40
Median
$3,890.45
Typical High
$12,302.69
BCBS
Setting
Professional
Modifier
Global
Typical Low
$1,174.90
Median
$1,230.27
Typical High
$4,265.80
Cigna
Setting
Facility
Modifier
Global
Typical Low
$1,995.26
Median
$5,623.41
Typical High
$12,302.69
Cigna
Setting
Professional
Modifier
Global
Typical Low
$1,445.44
Median
$3,388.44
Typical High
$6,918.31
United
Setting
Facility
Modifier
Global
Typical Low
$1,230.27
Median
$2,951.21
Typical High
$3,467.37
United
Setting
Professional
Modifier
Global
Typical Low
$1,230.27
Median
$1,737.80
Typical High
$3,890.45