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Large Multi-Gene Tumor Sequencing Panel

Kentucky rates for HCPCS 81455

This laboratory service analyzes a large panel of genes from a tumor or blood sample to look for genetic changes that can help guide cancer diagnosis and treatment decisions. It examines many genes at once using next-generation sequencing technology, offering a broader look than smaller, more targeted gene panels. Results can help identify mutations that inform prognosis or point toward targeted therapies.

Rates data updated October 2026.

How much does Large Multi-Gene Tumor Sequencing Panel cost?

$1,318

Typical negotiated rate. In Kentucky, October 2026.

Insurers have agreed to pay about $1,318 for this service. The price depends on where it is billed: about $1,175 from a physician practice, and about $2,951 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$1,175$794 to $2,344
FacilityA hospital or hospital-owned outpatient department$2,951$2,344 to $4,074

How much rates vary

Facilitymedian $2,951 · 10th to 90th $1,820 to $4,266Professionalmedian $1,175 · 10th to 90th $100 to $4,074
$100$200$500$1K$2K$5K$10Kfacility $2,951professional $1,175

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$724.44
Median
$2,344.23
Typical High
$2,454.71
Aetna
Setting
Professional
Modifier
None
Typical Low
$724.44
Median
$2,344.23
Typical High
$2,951.21
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$1,819.70
Median
$2,951.21
Typical High
$3,090.30
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$100.00
Median
$1,174.90
Typical High
$1,862.09
CareSource
Setting
Facility
Modifier
None
Typical Low
$2,951.21
Median
$3,467.37
Typical High
$4,073.80
CareSource
Setting
Professional
Modifier
None
Typical Low
$2,951.21
Median
$3,548.13
Typical High
$4,786.30
Cigna
Setting
Facility
Modifier
None
Typical Low
$2,290.87
Median
$4,265.80
Typical High
$6,165.95
Cigna
Setting
Professional
Modifier
None
Typical Low
$1,479.11
Median
$14,125.38
Typical High
$14,125.38
United
Setting
Professional
Modifier
None
Typical Low
$1,230.27
Median
$1,737.80
Typical High
$3,235.94
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$363.08
Median
$1,174.90
Typical High
$1,445.44
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$144.54
Median
$467.74
Typical High
$588.84

Where Kentucky sits

The same service costs 5.4 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Kentucky· 50th of 51

$1,318

AK $6,607AL $1,230

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.