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Large Multi-Gene Tumor Sequencing Panel

Pennsylvania rates for HCPCS 81455

This laboratory service analyzes a large panel of genes from a tumor or blood sample to look for genetic changes that can help guide cancer diagnosis and treatment decisions. It examines many genes at once using next-generation sequencing technology, offering a broader look than smaller, more targeted gene panels. Results can help identify mutations that inform prognosis or point toward targeted therapies.

Rates data updated July 2026.

Facilitymedian $3,981 · 10th–90th $1,585$9,7720%10%10th90th$3,981Professionalmedian $2,344 · 10th–90th $1,230$6,0260%50%10th90th$2,344$100.0$500.0$2.0K$10.0K$50.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$1,479.11
Median
$4,365.16
Typical High
$8,709.64
Aetna
Setting
Professional
Modifier
Global
Typical Low
$724.44
Median
$2,344.23
Typical High
$8,709.64
AmeriHealth
Setting
Facility
Modifier
Global
Typical Low
$1,548.82
Median
$3,548.13
Typical High
$29,512.09
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$9,120.11
Median
$14,125.38
Typical High
$19,952.62
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$2,290.87
Median
$2,290.87
Typical High
$2,290.87
Cigna
Setting
Facility
Modifier
Global
Typical Low
$2,089.30
Median
$4,466.84
Typical High
$8,511.38
Cigna
Setting
Professional
Modifier
Global
Typical Low
$1,548.82
Median
$3,090.30
Typical High
$6,606.93
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$1,380.38
Median
$2,041.74
Typical High
$4,265.80
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$2,951.21
Median
$2,951.21
Typical High
$2,951.21
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$2,187.76
Median
$3,388.44
Typical High
$5,495.41
Highmark BCBS
Setting
Facility
Modifier
Global
Typical Low
$2,511.89
Median
$5,011.87
Typical High
$10,000.00
Highmark BCBS
Setting
Professional
Modifier
Global
Typical Low
$2,187.76
Median
$2,187.76
Typical High
$2,187.76
Independence Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$1,584.89
Median
$3,311.31
Typical High
$6,918.31
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$1,995.26
Median
$4,365.16
Typical High
$8,709.64
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$1,862.09
Median
$2,398.83
Typical High
$8,709.64
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$2,951.21
Median
$13,182.57
Typical High
$27,542.29
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$2,570.40
Median
$2,951.21
Typical High
$2,951.21
United
Setting
Facility
Modifier
Global
Typical Low
$1,445.44
Median
$2,951.21
Typical High
$3,467.37
United
Setting
Professional
Modifier
Global
Typical Low
$1,230.27
Median
$1,737.80
Typical High
$4,365.16