go back

Large Multi-Gene Tumor Sequencing Panel

New York rates for HCPCS 81455

This laboratory service analyzes a large panel of genes from a tumor or blood sample to look for genetic changes that can help guide cancer diagnosis and treatment decisions. It examines many genes at once using next-generation sequencing technology, offering a broader look than smaller, more targeted gene panels. Results can help identify mutations that inform prognosis or point toward targeted therapies.

Rates data updated October 2026.

How much does Large Multi-Gene Tumor Sequencing Panel cost?

$2,291

Typical negotiated rate. In New York, October 2026.

Insurers have agreed to pay about $2,291 for this service. The price depends on where it is billed: about $2,138 from a physician practice, and about $5,012 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 11 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$2,138$1,175 to $3,311
FacilityA hospital or hospital-owned outpatient department$5,012$2,951 to $7,079

How much rates vary

Facilitymedian $5,012 · 10th to 90th $1,905 to $7,586Professionalmedian $2,138 · 10th to 90th $813 to $5,495
$100$1K$10Kfacility $5,012professional $2,138

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$2,290.87
Median
$3,630.78
Typical High
$12,882.50
Aetna
Setting
Professional
Modifier
None
Typical Low
$812.83
Median
$2,454.71
Typical High
$7,244.36
Ambetter
Setting
Professional
Modifier
None
Typical Low
$1,318.26
Median
$1,318.26
Typical High
$1,318.26
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$2,951.21
Median
$2,951.21
Typical High
$7,585.78
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$1,174.90
Median
$2,041.74
Typical High
$5,888.44
CDPHP
Setting
Professional
Modifier
None
Typical Low
$2,951.21
Median
$2,951.21
Typical High
$2,951.21
Cigna
Setting
Facility
Modifier
None
Typical Low
$2,818.38
Median
$6,309.57
Typical High
$8,317.64
Cigna
Setting
Professional
Modifier
None
Typical Low
$1,778.28
Median
$3,548.13
Typical High
$14,125.38
Emblem Health
Setting
Facility
Modifier
None
Typical Low
$2,951.21
Median
$4,786.30
Typical High
$7,943.28
Emblem Health
Setting
Professional
Modifier
None
Typical Low
$1,737.80
Median
$2,041.74
Typical High
$4,265.80
Excellus BCBS
Setting
Professional
Modifier
None
Typical Low
$1,905.46
Median
$2,951.21
Typical High
$3,388.44
Highmark BCBS
Setting
Facility
Modifier
None
Typical Low
$2,290.87
Median
$2,290.87
Typical High
$6,165.95
MVP Health Care
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$257.04
Typical High
$5,888.44
MVP Health Care
Setting
Professional
Modifier
None
Typical Low
$645.65
Median
$645.65
Typical High
$6,025.60
United
Setting
Facility
Modifier
None
Typical Low
$2,630.27
Median
$2,951.21
Typical High
$3,630.78
United
Setting
Professional
Modifier
None
Typical Low
$1,230.27
Median
$1,445.44
Typical High
$4,466.84
Univera
Setting
Facility
Modifier
None
Typical Low
$29.51
Median
$1,905.46
Typical High
$3,090.30
Univera
Setting
Professional
Modifier
None
Typical Low
$1,905.46
Median
$2,754.23
Typical High
$3,388.44
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$363.08
Median
$363.08
Typical High
$1,230.27
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$144.54
Median
$144.54
Typical High
$501.19

Where New York sits

The same service costs 5.4 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

New York· 33rd of 51

$2,291

AK $6,607AL $1,230

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.