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Large Multi-Gene Tumor Sequencing Panel

South Dakota rates for HCPCS 81455

This laboratory service analyzes a large panel of genes from a tumor or blood sample to look for genetic changes that can help guide cancer diagnosis and treatment decisions. It examines many genes at once using next-generation sequencing technology, offering a broader look than smaller, more targeted gene panels. Results can help identify mutations that inform prognosis or point toward targeted therapies.

Rates data updated October 2026.

How much does Large Multi-Gene Tumor Sequencing Panel cost?

$3,311

Typical negotiated rate. In South Dakota, October 2026.

Insurers have agreed to pay about $3,311 for this service. The price depends on where it is billed: about $2,951 from a physician practice, and about $3,311 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$2,951$2,291 to $5,623
FacilityA hospital or hospital-owned outpatient department$3,311$3,311 to $5,623

How much rates vary

Facilitymedian $3,311 · 10th to 90th $2,754 to $5,623Professionalmedian $2,951 · 10th to 90th $1,479 to $6,918
$2K$5K$10Kfacility $3,311professional $2,951

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$2,041.74
Median
$2,041.74
Typical High
$3,311.31
Aetna
Setting
Professional
Modifier
None
Typical Low
$1,949.84
Median
$1,949.84
Typical High
$2,754.23
Cigna
Setting
Facility
Modifier
None
Typical Low
$5,623.41
Median
$5,623.41
Typical High
$5,623.41
Cigna
Setting
Professional
Modifier
None
Typical Low
$3,388.44
Median
$5,623.41
Typical High
$6,918.31
Medica
Setting
Facility
Modifier
None
Typical Low
$2,754.23
Median
$3,311.31
Typical High
$5,370.32
Medica
Setting
Professional
Modifier
None
Typical Low
$1,479.11
Median
$2,630.27
Typical High
$5,370.32
Sanford Health Plan
Setting
Professional
Modifier
None
Typical Low
$4,365.16
Median
$6,760.83
Typical High
$7,943.28
United
Setting
Professional
Modifier
None
Typical Low
$1,230.27
Median
$1,737.80
Typical High
$2,951.21
Wellmark
Setting
Professional
Modifier
None
Typical Low
$2,951.21
Median
$2,951.21
Typical High
$2,951.21

Where South Dakota sits

The same service costs 5.4 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Dakota· 11th of 51

$3,311

AK $6,607AL $1,230

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.