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Large Multi-Gene Tumor Sequencing Panel

Massachusetts rates for HCPCS 81455

This laboratory service analyzes a large panel of genes from a tumor or blood sample to look for genetic changes that can help guide cancer diagnosis and treatment decisions. It examines many genes at once using next-generation sequencing technology, offering a broader look than smaller, more targeted gene panels. Results can help identify mutations that inform prognosis or point toward targeted therapies.

Rates data updated July 2026.

Facilitymedian $5,754 · 10th–90th $2,138$9,3330%10%10th90th$5,754Professionalmedian $2,951 · 10th–90th $724$7,2440%20%40%10th90th$2,951$100.0$500.0$2.0K$10.0K$50.0K

Distribution of negotiated rates across all payers (price axis is log-scale). Facility and professional rates are different services and are charted separately. Need provider-level prices? Contact us.

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$724.44
Median
$5,011.87
Typical High
$9,549.93
Aetna
Setting
Professional
Modifier
Global
Typical Low
$724.44
Median
$724.44
Typical High
$8,709.64
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$2,137.96
Median
$3,311.31
Typical High
$13,803.84
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$1,737.80
Median
$2,951.21
Typical High
$8,511.38
BCBS
Setting
Facility
Modifier
Global
Typical Low
$4,677.35
Median
$5,754.40
Typical High
$8,317.64
BCBS
Setting
Professional
Modifier
Global
Typical Low
$602.56
Median
$602.56
Typical High
$2,884.03
Cigna
Setting
Facility
Modifier
Global
Typical Low
$1,905.46
Median
$2,290.87
Typical High
$4,677.35
Cigna
Setting
Professional
Modifier
Global
Typical Low
$1,584.89
Median
$3,090.30
Typical High
$6,025.60
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$83.18
Median
$4,897.79
Typical High
$9,772.37
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$2,187.76
Median
$4,168.69
Typical High
$5,011.87
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$2,951.21
Median
$2,951.21
Typical High
$5,370.32
Health New England
Setting
Facility
Modifier
Global
Typical Low
$2,290.87
Median
$6,309.57
Typical High
$6,309.57
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$2,137.96
Median
$3,311.31
Typical High
$13,803.84
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$1,737.80
Median
$2,951.21
Typical High
$8,511.38
United
Setting
Facility
Modifier
Global
Typical Low
$1,621.81
Median
$2,951.21
Typical High
$3,467.37
United
Setting
Professional
Modifier
Global
Typical Low
$1,737.80
Median
$2,951.21
Typical High
$5,888.44