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Tissue Marker Measurement, Manual Method

Pennsylvania rates for HCPCS 88369

This laboratory service is an additional measurement performed on a tissue sample already being analyzed under a microscope, with a pathologist visually counting and scoring the result rather than using computer-assisted image analysis, to quantify how much of a specific marker is present. It's used to help characterize a tumor in more detail and can guide decisions about treatment. It's billed in addition to the main tissue analysis rather than as a stand-alone test.

Rates data updated October 2026.

How much does Tissue Marker Measurement, Manual Method cost?

$126

Typical negotiated rate. In Pennsylvania, October 2026.

Insurers have agreed to pay about $126 for this service. The price depends on where it is billed: about $126 from a physician practice, and about $155 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$126$87.10 to $155
FacilityA hospital or hospital-owned outpatient department$155$117 to $525

How much rates vary

Facilitymedian $155 · 10th to 90th $89 to $912Professionalmedian $126 · 10th to 90th $66 to $214
$100$1K$10Kfacility $155professional $126

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$89.13
Median
$107.15
Typical High
$151.36
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$75.86
Median
$89.13
Typical High
$107.15
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$22.91
Median
$25.70
Typical High
$28.18
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$52.48
Median
$64.57
Typical High
$77.62
Capital Blue Cross
Setting
Facility
Modifier
None
Typical Low
$4,265.80
Median
$5,011.87
Typical High
$79,432.82
Capital Blue Cross
Setting
Facility
Modifier
TC · Technical part
Typical Low
$177.83
Median
$229.09
Typical High
$5,011.87
Capital Blue Cross
Setting
Professional
Modifier
None (both parts)
Typical Low
$125.89
Median
$138.04
Typical High
$245.47
Capital Blue Cross
Setting
Professional
Modifier
26 · Professional part
Typical Low
$33.11
Median
$48.98
Typical High
$79.43
Capital Blue Cross
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$97.72
Typical High
$169.82
Cigna
Setting
Facility
Modifier
None
Typical Low
$91.20
Median
$147.91
Typical High
$239.88
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$42.66
Median
$72.44
Typical High
$144.54
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$13.80
Median
$25.70
Typical High
$42.66
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$28.84
Median
$50.12
Typical High
$107.15
Emblem Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$97.72
Median
$194.98
Typical High
$194.98
Geisinger
Setting
Professional
Modifier
None (both parts)
Typical Low
$69.18
Median
$128.82
Typical High
$213.80
Geisinger
Setting
Professional
Modifier
26 · Professional part
Typical Low
$24.55
Median
$35.48
Typical High
$58.88
Geisinger
Setting
Professional
Modifier
TC · Technical part
Typical Low
$45.71
Median
$95.50
Typical High
$154.88
Highmark BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$33.88
Median
$33.88
Typical High
$33.88
Martin's Point
Setting
Facility
Modifier
None
Typical Low
$107.15
Median
$107.15
Typical High
$151.36
Martin's Point
Setting
Professional
Modifier
None (both parts)
Typical Low
$75.86
Median
$89.13
Typical High
$107.15
Martin's Point
Setting
Professional
Modifier
26 · Professional part
Typical Low
$22.91
Median
$25.70
Typical High
$28.18
Martin's Point
Setting
Professional
Modifier
TC · Technical part
Typical Low
$52.48
Median
$64.57
Typical High
$77.62
UPMC Health Plan
Setting
Facility
Modifier
None
Typical Low
$77.62
Median
$457.09
Typical High
$741.31
UPMC Health Plan
Setting
Professional
Modifier
None (both parts)
Typical Low
$77.62
Median
$77.62
Typical High
$117.49
UPMC Health Plan
Setting
Professional
Modifier
26 · Professional part
Typical Low
$26.92
Median
$26.92
Typical High
$31.62
UPMC Health Plan
Setting
Professional
Modifier
TC · Technical part
Typical Low
$50.12
Median
$50.12
Typical High
$85.11
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$61.66
Median
$109.65
Typical High
$173.78
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$18.20
Median
$33.11
Typical High
$52.48
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$42.66
Median
$77.62
Typical High
$125.89
5 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$43.65
Median
$44.67
Typical High
$53.70
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$17.38
Median
$18.20
Typical High
$21.38
Highmark BCBS
Setting
Facility
Modifier
XU · Unusual separate service
Typical Low
$66.07
Median
$66.07
Typical High
$66.07
Martin's Point
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$43.65
Median
$44.67
Typical High
$53.70
Martin's Point
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$17.38
Median
$18.20
Typical High
$21.38

Where Pennsylvania sits

The same service costs 4.6 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 22nd of 51

$126

AK $269AL $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.