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Tissue Marker Measurement, Manual Method

North Carolina rates for HCPCS 88369

This laboratory service is an additional measurement performed on a tissue sample already being analyzed under a microscope, with a pathologist visually counting and scoring the result rather than using computer-assisted image analysis, to quantify how much of a specific marker is present. It's used to help characterize a tumor in more detail and can guide decisions about treatment. It's billed in addition to the main tissue analysis rather than as a stand-alone test.

Rates data updated October 2026.

How much does Tissue Marker Measurement, Manual Method cost?

$102

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $102 for this service. The price depends on where it is billed: about $102 from a physician practice, and about $151 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$102$64.57 to $115
FacilityA hospital or hospital-owned outpatient department$151$89.13 to $331

How much rates vary

Facilitymedian $151 · 10th to 90th $78 to $427Professionalmedian $102 · 10th to 90th $37 to $174
$50$100$200$500facility $151professional $102

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$89.13
Median
$89.13
Typical High
$89.13
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$75.86
Median
$89.13
Typical High
$239.88
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$22.91
Median
$25.12
Typical High
$41.69
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$52.48
Median
$63.10
Typical High
$100.00
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$295.12
Median
$295.12
Typical High
$295.12
BCBS North Carolina
Setting
Professional
Modifier
26 · Professional part
Typical Low
$30.90
Median
$45.71
Typical High
$64.57
BCBS North Carolina
Setting
Professional
Modifier
TC · Technical part
Typical Low
$72.44
Median
$83.18
Typical High
$144.54
Cigna
Setting
Facility
Modifier
None
Typical Low
$72.44
Median
$208.93
Typical High
$426.58
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$36.31
Median
$57.54
Typical High
$162.18
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$12.88
Median
$15.85
Typical High
$46.77
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$23.44
Median
$41.69
Typical High
$104.71
Medcost
Setting
Facility
Modifier
None
Typical Low
$89.13
Median
$89.13
Typical High
$144.54
Medcost
Setting
Professional
Modifier
None (both parts)
Typical Low
$104.71
Median
$104.71
Typical High
$131.83
Medcost
Setting
Professional
Modifier
26 · Professional part
Typical Low
$37.15
Median
$37.15
Typical High
$41.69
Medcost
Setting
Professional
Modifier
TC · Technical part
Typical Low
$67.61
Median
$67.61
Typical High
$107.15
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$61.66
Median
$74.13
Typical High
$199.53
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$18.62
Median
$24.55
Typical High
$57.54
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$42.66
Median
$53.70
Typical High
$131.83
7 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$43.65
Median
$43.65
Typical High
$51.29
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$17.78
Median
$17.78
Typical High
$20.42
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$52.48
Median
$52.48
Typical High
$109.65
Medcost
Setting
Professional
Modifier
80 · Assistant surgeon
Typical Low
$20.89
Median
$20.89
Typical High
$43.65
Medcost
Setting
Professional
Modifier
81 · Minimal assistant surgeon
Typical Low
$14.79
Median
$14.79
Typical High
$30.90
Medcost
Setting
Professional
Modifier
82 · Assistant surgeon, no resident
Typical Low
$14.79
Median
$14.79
Typical High
$30.90
Medcost
Setting
Professional
Modifier
AS · PA/NP assist
Typical Low
$14.79
Median
$14.79
Typical High
$30.90

Where North Carolina sits

The same service costs 4.6 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 37th of 51

$102

AK $269AL $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.