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Tissue Marker Measurement, Manual Method

Missouri rates for HCPCS 88369

This laboratory service is an additional measurement performed on a tissue sample already being analyzed under a microscope, with a pathologist visually counting and scoring the result rather than using computer-assisted image analysis, to quantify how much of a specific marker is present. It's used to help characterize a tumor in more detail and can guide decisions about treatment. It's billed in addition to the main tissue analysis rather than as a stand-alone test.

Rates data updated October 2026.

How much does Tissue Marker Measurement, Manual Method cost?

$117

Typical negotiated rate. In Missouri, October 2026.

Insurers have agreed to pay about $117 for this service. The price depends on where it is billed: about $115 from a physician practice, and about $182 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$115$70.79 to $282
FacilityA hospital or hospital-owned outpatient department$182$107 to $263

How much rates vary

Facilitymedian $182 · 10th to 90th $91 to $589Professionalmedian $115 · 10th to 90th $56 to $724
$50$100$200$500facility $182professional $115

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$42.66
Median
$102.33
Typical High
$114.82
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$97.72
Median
$114.82
Typical High
$165.96
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$26.92
Median
$28.18
Typical High
$42.66
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$70.79
Median
$77.62
Typical High
$109.65
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$22.39
Median
$22.39
Typical High
$22.39
Anthem BCBS
Setting
Professional
Modifier
None (both parts)
Typical Low
$44.67
Median
$74.13
Typical High
$281.84
Anthem BCBS
Setting
Professional
Modifier
26 · Professional part
Typical Low
$13.49
Median
$25.70
Typical High
$97.72
Anthem BCBS
Setting
Professional
Modifier
TC · Technical part
Typical Low
$30.90
Median
$46.77
Typical High
$181.97
BCBS Kansas City
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$102.33
Typical High
$194.98
BCBS Kansas City
Setting
Professional
Modifier
None (both parts)
Typical Low
$83.18
Median
$125.89
Typical High
$208.93
Cigna
Setting
Facility
Modifier
None
Typical Low
$64.57
Median
$208.93
Typical High
$316.23
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$38.02
Median
$61.66
Typical High
$151.36
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$13.18
Median
$15.85
Typical High
$48.98
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$25.12
Median
$45.71
Typical High
$112.20
Medica
Setting
Facility
Modifier
None
Typical Low
$93.33
Median
$194.98
Typical High
$588.84
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$75.86
Median
$724.44
Typical High
$724.44
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$26.30
Median
$199.53
Typical High
$199.53
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$51.29
Median
$537.03
Typical High
$537.03
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$66.07
Median
$114.82
Typical High
$309.03
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$19.50
Median
$33.88
Typical High
$83.18
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$47.86
Median
$79.43
Typical High
$223.87
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$48.98
Median
$52.48
Typical High
$69.18
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$19.95
Median
$20.89
Typical High
$27.54

Where Missouri sits

The same service costs 4.6 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 27th of 51

$117

AK $269AL $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.