go back

Tissue Marker Measurement, Manual Method

Minnesota rates for HCPCS 88369

This laboratory service is an additional measurement performed on a tissue sample already being analyzed under a microscope, with a pathologist visually counting and scoring the result rather than using computer-assisted image analysis, to quantify how much of a specific marker is present. It's used to help characterize a tumor in more detail and can guide decisions about treatment. It's billed in addition to the main tissue analysis rather than as a stand-alone test.

Rates data updated October 2026.

How much does Tissue Marker Measurement, Manual Method cost?

$224

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $224 for this service. The price depends on where it is billed: about $219 from a physician practice, and about $316 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$219$174 to $324
FacilityA hospital or hospital-owned outpatient department$316$120 to $331

How much rates vary

Facilitymedian $316 · 10th to 90th $120 to $537Professionalmedian $219 · 10th to 90th $120 to $447
$100$200$500$1Kfacility $316professional $219

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$120.23
Median
$120.23
Typical High
$331.13
Aetna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$30.20
Median
$30.20
Typical High
$30.20
Aetna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$91.20
Median
$91.20
Typical High
$91.20
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$95.50
Median
$120.23
Typical High
$120.23
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$26.92
Median
$30.20
Typical High
$38.02
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$77.62
Median
$91.20
Typical High
$91.20
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$169.82
Median
$223.87
Typical High
$363.08
BCBS Minnesota
Setting
Professional
Modifier
None (both parts)
Typical Low
$177.83
Median
$302.00
Typical High
$478.63
BCBS Minnesota
Setting
Professional
Modifier
26 · Professional part
Typical Low
$44.67
Median
$75.86
Typical High
$120.23
BCBS Minnesota
Setting
Professional
Modifier
TC · Technical part
Typical Low
$128.82
Median
$234.42
Typical High
$363.08
Cigna
Setting
Facility
Modifier
None
Typical Low
$288.40
Median
$457.09
Typical High
$1,348.96
Cigna
Setting
Facility
Modifier
26 · Professional part
Typical Low
$72.44
Median
$114.82
Typical High
$331.13
Cigna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$218.78
Median
$346.74
Typical High
$1,000.00
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$173.78
Median
$190.55
Typical High
$257.04
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$43.65
Median
$47.86
Typical High
$64.57
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$131.83
Median
$144.54
Typical High
$194.98
Health Partners
Setting
Facility
Modifier
None
Typical Low
$269.15
Median
$436.52
Typical High
$1,047.13
Health Partners
Setting
Facility
Modifier
26 · Professional part
Typical Low
$67.61
Median
$109.65
Typical High
$263.03
Health Partners
Setting
Facility
Modifier
TC · Technical part
Typical Low
$204.17
Median
$331.13
Typical High
$794.33
Health Partners
Setting
Professional
Modifier
None (both parts)
Typical Low
$173.78
Median
$173.78
Typical High
$245.47
Health Partners
Setting
Professional
Modifier
26 · Professional part
Typical Low
$42.66
Median
$42.66
Typical High
$60.26
Health Partners
Setting
Professional
Modifier
TC · Technical part
Typical Low
$128.82
Median
$128.82
Typical High
$181.97
Medica
Setting
Facility
Modifier
None
Typical Low
$147.91
Median
$199.53
Typical High
$309.03
Medica
Setting
Professional
Modifier
None (both parts)
Typical Low
$87.10
Median
$245.47
Typical High
$724.44
Medica
Setting
Professional
Modifier
26 · Professional part
Typical Low
$32.36
Median
$75.86
Typical High
$199.53
Medica
Setting
Professional
Modifier
TC · Technical part
Typical Low
$60.26
Median
$173.78
Typical High
$537.03
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$77.62
Median
$194.98
Typical High
$338.84
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$20.42
Median
$60.26
Typical High
$100.00
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$57.54
Median
$138.04
Typical High
$239.88
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$60.26
Median
$60.26
Typical High
$60.26
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$23.99
Median
$23.99
Typical High
$23.99
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$60.26
Median
$60.26
Typical High
$60.26
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$23.99
Median
$23.99
Typical High
$23.99

Where Minnesota sits

The same service costs 4.6 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 4th of 51

$224

AK $269AL $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.