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Tissue Marker Measurement, Manual Method

Maryland rates for HCPCS 88369

This laboratory service is an additional measurement performed on a tissue sample already being analyzed under a microscope, with a pathologist visually counting and scoring the result rather than using computer-assisted image analysis, to quantify how much of a specific marker is present. It's used to help characterize a tumor in more detail and can guide decisions about treatment. It's billed in addition to the main tissue analysis rather than as a stand-alone test.

Rates data updated October 2026.

How much does Tissue Marker Measurement, Manual Method cost?

$107

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $107 for this service. Most negotiated rates run $91.20 to $132.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $107 · 10th to 90th $69 to $151
$50$100$200professional $107

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$93.33
Median
$97.72
Typical High
$109.65
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$25.12
Median
$25.70
Typical High
$26.92
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$60.26
Median
$72.44
Typical High
$83.18
CareFirst
Setting
Professional
Modifier
None (both parts)
Typical Low
$91.20
Median
$117.49
Typical High
$131.83
CareFirst
Setting
Professional
Modifier
26 · Professional part
Typical Low
$28.18
Median
$28.18
Typical High
$31.62
CareFirst
Setting
Professional
Modifier
TC · Technical part
Typical Low
$85.11
Median
$91.20
Typical High
$114.82
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$54.95
Median
$66.07
Typical High
$251.19
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$14.45
Median
$17.38
Typical High
$60.26
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$38.90
Median
$51.29
Typical High
$190.55
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$138.04
Median
$165.96
Typical High
$204.17
Kaiser Permanente
Setting
Professional
Modifier
26 · Professional part
Typical Low
$33.11
Median
$41.69
Typical High
$50.12
Kaiser Permanente
Setting
Professional
Modifier
TC · Technical part
Typical Low
$104.71
Median
$125.89
Typical High
$158.49
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$52.48
Median
$89.13
Typical High
$229.09
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$16.60
Median
$25.70
Typical High
$61.66
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$35.48
Median
$66.07
Typical High
$169.82
Wellpoint
Setting
Professional
Modifier
None (both parts)
Typical Low
$97.72
Median
$97.72
Typical High
$213.80
Wellpoint
Setting
Professional
Modifier
26 · Professional part
Typical Low
$28.18
Median
$28.18
Typical High
$50.12
Wellpoint
Setting
Professional
Modifier
TC · Technical part
Typical Low
$69.18
Median
$69.18
Typical High
$165.96
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$45.71
Median
$48.98
Typical High
$54.95
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$18.62
Median
$19.50
Typical High
$21.88

Where Maryland sits

The same service costs 4.6 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 33rd of 51

$107

AK $269AL $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.