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Tissue Marker Measurement, Manual Method

Massachusetts rates for HCPCS 88369

This laboratory service is an additional measurement performed on a tissue sample already being analyzed under a microscope, with a pathologist visually counting and scoring the result rather than using computer-assisted image analysis, to quantify how much of a specific marker is present. It's used to help characterize a tumor in more detail and can guide decisions about treatment. It's billed in addition to the main tissue analysis rather than as a stand-alone test.

Rates data updated October 2026.

How much does Tissue Marker Measurement, Manual Method cost?

$162

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $162 for this service. The price depends on where it is billed: about $162 from a physician practice, and about $148 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$162$81.28 to $339
FacilityA hospital or hospital-owned outpatient department$148$95.50 to $182

How much rates vary

Facilitymedian $148 · 10th to 90th $45 to $257Professionalmedian $162 · 10th to 90th $58 to $724
$50$100$200$500$1K$2K$5Kfacility $148professional $162

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$57.54
Median
$57.54
Typical High
$57.54
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$57.54
Median
$57.54
Typical High
$75.86
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$18.20
Median
$18.20
Typical High
$22.91
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$39.81
Median
$39.81
Typical High
$52.48
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$147.91
Median
$363.08
Typical High
$457.09
AllWays Health Partners
Setting
Professional
Modifier
None (both parts)
Typical Low
$81.28
Median
$363.08
Typical High
$724.44
AllWays Health Partners
Setting
Professional
Modifier
26 · Professional part
Typical Low
$21.88
Median
$85.11
Typical High
$199.53
AllWays Health Partners
Setting
Professional
Modifier
TC · Technical part
Typical Low
$58.88
Median
$281.84
Typical High
$537.03
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$141.25
Median
$199.53
Typical High
$281.84
BCBS Massachusetts
Setting
Professional
Modifier
None (both parts)
Typical Low
$154.88
Median
$154.88
Typical High
$269.15
BCBS Massachusetts
Setting
Professional
Modifier
26 · Professional part
Typical Low
$36.31
Median
$36.31
Typical High
$61.66
Cigna
Setting
Facility
Modifier
None
Typical Low
$46.77
Median
$95.50
Typical High
$165.96
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$67.61
Median
$131.83
Typical High
$295.12
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$17.38
Median
$37.15
Typical High
$75.86
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$51.29
Median
$91.20
Typical High
$218.78
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$42.66
Median
$138.04
Typical High
$213.80
Fallon Health
Setting
Professional
Modifier
None (both parts)
Typical Low
$44.67
Median
$147.91
Typical High
$213.80
Harvard Pilgrim
Setting
Professional
Modifier
None (both parts)
Typical Low
$81.28
Median
$257.04
Typical High
$389.05
Harvard Pilgrim
Setting
Professional
Modifier
26 · Professional part
Typical Low
$21.88
Median
$63.10
Typical High
$97.72
Harvard Pilgrim
Setting
Professional
Modifier
TC · Technical part
Typical Low
$58.88
Median
$190.55
Typical High
$295.12
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$147.91
Median
$363.08
Typical High
$457.09
Mass General Brigham
Setting
Professional
Modifier
None (both parts)
Typical Low
$81.28
Median
$363.08
Typical High
$724.44
Mass General Brigham
Setting
Professional
Modifier
26 · Professional part
Typical Low
$21.88
Median
$85.11
Typical High
$199.53
Mass General Brigham
Setting
Professional
Modifier
TC · Technical part
Typical Low
$58.88
Median
$281.84
Typical High
$537.03
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$63.10
Median
$123.03
Typical High
$338.84
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$19.50
Median
$34.67
Typical High
$91.20
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$41.69
Median
$87.10
Typical High
$263.03
Well Sense
Setting
Facility
Modifier
None
Typical Low
$95.50
Median
$131.83
Typical High
$194.98
Well Sense
Setting
Facility
Modifier
26 · Professional part
Typical Low
$23.99
Median
$31.62
Typical High
$56.23
Well Sense
Setting
Facility
Modifier
TC · Technical part
Typical Low
$72.44
Median
$93.33
Typical High
$165.96
Well Sense
Setting
Professional
Modifier
None (both parts)
Typical Low
$53.70
Median
$53.70
Typical High
$64.57
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$28.84
Median
$28.84
Typical High
$28.84
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$11.48
Median
$11.48
Typical High
$11.48

Where Massachusetts sits

The same service costs 4.6 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 14th of 51

$162

AK $269AL $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.