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Tissue Marker Measurement, Manual Method

Illinois rates for HCPCS 88369

This laboratory service is an additional measurement performed on a tissue sample already being analyzed under a microscope, with a pathologist visually counting and scoring the result rather than using computer-assisted image analysis, to quantify how much of a specific marker is present. It's used to help characterize a tumor in more detail and can guide decisions about treatment. It's billed in addition to the main tissue analysis rather than as a stand-alone test.

Rates data updated October 2026.

How much does Tissue Marker Measurement, Manual Method cost?

$120

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $120 for this service. The price depends on where it is billed: about $105 from a physician practice, and about $339 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$105$53.70 to $178
FacilityA hospital or hospital-owned outpatient department$339$174 to $525

How much rates vary

Facilitymedian $339 · 10th to 90th $110 to $1,349Professionalmedian $105 · 10th to 90th $36 to $204
$50$100$200$500$1K$2Kfacility $339professional $105

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$97.72
Median
$138.04
Typical High
$389.05
Aetna
Setting
Facility
Modifier
TC · Technical part
Typical Low
$77.62
Median
$147.91
Typical High
$295.12
Aetna
Setting
Professional
Modifier
None (both parts)
Typical Low
$89.13
Median
$104.71
Typical High
$144.54
Aetna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$25.70
Median
$27.54
Typical High
$38.02
Aetna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$70.79
Median
$77.62
Typical High
$107.15
Ambetter
Setting
Professional
Modifier
26 · Professional part
Typical Low
$14.79
Median
$14.79
Typical High
$14.79
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$323.59
Median
$524.81
Typical High
$2,691.53
BCBS Illinois
Setting
Professional
Modifier
None (both parts)
Typical Low
$36.31
Median
$97.72
Typical High
$204.17
Cigna
Setting
Facility
Modifier
None
Typical Low
$107.15
Median
$181.97
Typical High
$398.11
Cigna
Setting
Professional
Modifier
None (both parts)
Typical Low
$57.54
Median
$64.57
Typical High
$181.97
Cigna
Setting
Professional
Modifier
26 · Professional part
Typical Low
$15.85
Median
$19.05
Typical High
$48.98
Cigna
Setting
Professional
Modifier
TC · Technical part
Typical Low
$38.02
Median
$48.98
Typical High
$131.83
Hally Health
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$190.55
Typical High
$416.87
Hally Health
Setting
Professional
Modifier
26 · Professional part
Typical Low
$38.02
Median
$50.12
Typical High
$234.42
Hally Health
Setting
Professional
Modifier
TC · Technical part
Typical Low
$93.33
Median
$134.90
Typical High
$245.47
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Molina
Setting
Professional
Modifier
None (both parts)
Typical Low
$33.11
Median
$33.11
Typical High
$33.11
United
Setting
Professional
Modifier
None (both parts)
Typical Low
$72.44
Median
$117.49
Typical High
$213.80
United
Setting
Professional
Modifier
26 · Professional part
Typical Low
$20.89
Median
$33.88
Typical High
$61.66
United
Setting
Professional
Modifier
TC · Technical part
Typical Low
$48.98
Median
$81.28
Typical High
$151.36
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$46.77
Median
$75.86
Typical High
$194.98
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$18.62
Median
$30.20
Typical High
$77.62
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$47.86
Median
$52.48
Typical High
$52.48
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$19.05
Median
$20.89
Typical High
$20.89

Where Illinois sits

The same service costs 4.6 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 25th of 51

$120

AK $269AL $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.