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Lung Cancer Outlook Signature Test

Maryland rates for HCPCS 81538

A specialized laboratory test used in advanced lung cancer that measures a set of markers in a patient sample and combines them into a single result placing the person in a better or poorer outlook group. The result is used to help judge which type of treatment is most likely to benefit them.

Rates data updated October 2026.

How much does Lung Cancer Outlook Signature Test cost?

$2,138

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $2,138 for this service. Most negotiated rates run $1,905 to $2,291.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $2,138 · 10th to 90th $1,288 to $2,884
$1K$2K$5Kprofessional $2,138

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$2,137.96
Median
$2,137.96
Typical High
$2,187.76
CareFirst
Setting
Professional
Modifier
None
Typical Low
$2,089.30
Median
$2,290.87
Typical High
$2,290.87
Cigna
Setting
Professional
Modifier
None
Typical Low
$1,479.11
Median
$2,290.87
Typical High
$8,317.64
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$2,884.03
Median
$3,467.37
Typical High
$4,265.80
United
Setting
Professional
Modifier
None
Typical Low
$891.25
Median
$1,445.44
Typical High
$2,398.83
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$2,290.87
Median
$2,290.87
Typical High
$2,290.87
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$1,071.52
Median
$1,071.52
Typical High
$1,096.48
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$426.58
Median
$426.58
Typical High
$436.52

Where Maryland sits

The same service costs 5.4 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 32nd of 51

$2,138

AK $6,457AL $1,202

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.