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Mitochondrial DNA Large Deletion Test

Pennsylvania rates for HCPCS 81465

A laboratory test that examines the DNA inside mitochondria, the structures that generate energy inside cells, looking for large missing sections. It also reports what proportion of a person's mitochondria carry the change, since this varies from cell to cell and from tissue to tissue.

Rates data updated October 2026.

How much does Mitochondrial DNA Large Deletion Test cost?

$776

Typical negotiated rate. In Pennsylvania, October 2026.

Insurers have agreed to pay about $776 for this service. The price depends on where it is billed: about $759 from a physician practice, and about $1,175 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$759$724 to $933
FacilityA hospital or hospital-owned outpatient department$1,175$933 to $2,754

How much rates vary

Facilitymedian $1,175 · 10th to 90th $759 to $4,786Professionalmedian $759 · 10th to 90th $550 to $1,380
$500$1K$2K$5K$10K$20K$50Kfacility $1,175professional $759

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$758.58
Median
$758.58
Typical High
$2,754.23
Aetna
Setting
Professional
Modifier
None
Typical Low
$758.58
Median
$758.58
Typical High
$891.25
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$380.19
Median
$380.19
Typical High
$446.68
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$151.36
Median
$151.36
Typical High
$177.83
Capital Blue Cross
Setting
Facility
Modifier
None
Typical Low
$3,630.78
Median
$4,786.30
Typical High
$6,606.93
Capital Blue Cross
Setting
Professional
Modifier
None
Typical Low
$660.69
Median
$724.44
Typical High
$2,238.72
Cigna
Setting
Facility
Modifier
None
Typical Low
$660.69
Median
$1,412.54
Typical High
$2,818.38
Cigna
Setting
Professional
Modifier
None
Typical Low
$602.56
Median
$1,000.00
Typical High
$1,445.44
Emblem Health
Setting
Professional
Modifier
None
Typical Low
$436.52
Median
$660.69
Typical High
$1,230.27
Geisinger
Setting
Facility
Modifier
None
Typical Low
$933.25
Median
$933.25
Typical High
$933.25
Geisinger
Setting
Professional
Modifier
None
Typical Low
$707.95
Median
$1,071.52
Typical High
$1,819.70
Highmark BCBS
Setting
Facility
Modifier
None
Typical Low
$1,621.81
Median
$1,621.81
Typical High
$1,621.81
Highmark BCBS
Setting
Professional
Modifier
None
Typical Low
$562.34
Median
$562.34
Typical High
$562.34
Martin's Point
Setting
Facility
Modifier
None
Typical Low
$758.58
Median
$758.58
Typical High
$3,235.94
Martin's Point
Setting
Professional
Modifier
None
Typical Low
$758.58
Median
$758.58
Typical High
$794.33
Martin's Point
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$380.19
Median
$380.19
Typical High
$398.11
Martin's Point
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$151.36
Median
$151.36
Typical High
$158.49
UPMC Health Plan
Setting
Facility
Modifier
None
Typical Low
$933.25
Median
$1,023.29
Typical High
$2,290.87
UPMC Health Plan
Setting
Professional
Modifier
None
Typical Low
$933.25
Median
$1,023.29
Typical High
$1,023.29
United
Setting
Facility
Modifier
None
Typical Low
$851.14
Median
$933.25
Typical High
$1,122.02
United
Setting
Professional
Modifier
None
Typical Low
$389.05
Median
$562.34
Typical High
$1,174.90

Where Pennsylvania sits

The same service costs 3.7 times more in Alaska than in Georgia. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 32nd of 51

$776

AK $2,089GA $562

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.