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Mitochondrial DNA Large Deletion Test

Pennsylvania rates for HCPCS 81465

A laboratory test that examines the DNA inside mitochondria, the structures that generate energy inside cells, looking for large missing sections. It also reports what proportion of a person's mitochondria carry the change, since this varies from cell to cell and from tissue to tissue.

Rates data updated July 2026.

How much does Mitochondrial DNA Large Deletion Test cost?

$891

Typical negotiated rate. In Pennsylvania, July 2026.

Insurers have agreed to pay about $891 for this service. The price depends on where it is billed: about $794 from a physician practice, and about $1,549 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$794$759 to $1,148
FacilityA hospital or hospital-owned outpatient department$1,549$1,000 to $2,754

How much rates vary

Facilitymedian $1,549 · 10th to 90th $759 to $3,715Professionalmedian $794 · 10th to 90th $724 to $1,622
$500.0$1.0K$2.0K$5.0K$10.0K$20.0K$50.0Kfacility $1,549professional $794

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$794.33
Median
$1,584.89
Typical High
$3,548.13
Aetna
Setting
Professional
Modifier
Global
Typical Low
$741.31
Median
$794.33
Typical High
$2,344.23
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$3,388.44
Median
$4,570.88
Typical High
$8,511.38
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$724.44
Median
$724.44
Typical High
$724.44
Cigna
Setting
Facility
Modifier
Global
Typical Low
$676.08
Median
$1,412.54
Typical High
$2,754.23
Cigna
Setting
Professional
Modifier
Global
Typical Low
$489.78
Median
$1,047.13
Typical High
$2,137.96
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$436.52
Median
$660.69
Typical High
$1,348.96
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$933.25
Median
$933.25
Typical High
$933.25
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$707.95
Median
$1,071.52
Typical High
$1,778.28
Highmark BCBS
Setting
Facility
Modifier
Global
Typical Low
$1,621.81
Median
$1,621.81
Typical High
$1,621.81
Highmark BCBS
Setting
Professional
Modifier
Global
Typical Low
$562.34
Median
$562.34
Typical High
$660.69
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$758.58
Median
$1,548.82
Typical High
$3,311.31
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$741.31
Median
$794.33
Typical High
$2,754.23
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$933.25
Median
$1,023.29
Typical High
$2,290.87
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$831.76
Median
$933.25
Typical High
$1,023.29
United
Setting
Facility
Modifier
Global
Typical Low
$467.74
Median
$933.25
Typical High
$1,122.02
United
Setting
Professional
Modifier
Global
Typical Low
$389.05
Median
$562.34
Typical High
$1,412.54

Where Pennsylvania sits

The same service costs 2.0 times more in South Dakota than in Washington, DC. Every bar is a state, most expensive first. Pick one to see its carriers and full range.

Pennsylvania $891 · 28th of 51
SD $1,413DC $708

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.