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Mitochondrial DNA Large Deletion Test

Massachusetts rates for HCPCS 81465

A laboratory test that examines the DNA inside mitochondria, the structures that generate energy inside cells, looking for large missing sections. It also reports what proportion of a person's mitochondria carry the change, since this varies from cell to cell and from tissue to tissue.

Rates data updated October 2026.

How much does Mitochondrial DNA Large Deletion Test cost?

$1,148

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $1,148 for this service. The price depends on where it is billed: about $1,072 from a physician practice, and about $1,349 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$1,072$562 to $2,291
FacilityA hospital or hospital-owned outpatient department$1,349$832 to $1,862

How much rates vary

Facilitymedian $1,349 · 10th to 90th $692 to $2,754Professionalmedian $1,072 · 10th to 90th $468 to $4,677
$100$200$500$1K$2K$5Kfacility $1,349professional $1,072

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$1,148.15
Median
$1,148.15
Typical High
$1,148.15
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$691.83
Median
$977.24
Typical High
$2,754.23
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$467.74
Median
$1,412.54
Typical High
$4,677.35
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$1,479.11
Median
$2,089.30
Typical High
$3,019.95
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$870.96
Median
$870.96
Typical High
$912.01
Cigna
Setting
Facility
Modifier
None
Typical Low
$616.60
Median
$691.83
Typical High
$1,659.59
Cigna
Setting
Professional
Modifier
None
Typical Low
$501.19
Median
$977.24
Typical High
$3,630.78
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$1,348.96
Median
$1,584.89
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$1,348.96
Median
$1,348.96
Typical High
$1,584.89
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$467.74
Median
$933.25
Typical High
$1,995.26
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$691.83
Median
$977.24
Typical High
$2,754.23
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$467.74
Median
$1,412.54
Typical High
$4,677.35
United
Setting
Facility
Modifier
None
Typical Low
$851.14
Median
$933.25
Typical High
$1,122.02
United
Setting
Professional
Modifier
None
Typical Low
$371.54
Median
$562.34
Typical High
$1,778.28
Well Sense
Setting
Facility
Modifier
None
Typical Low
$831.76
Median
$1,148.15
Typical High
$2,511.89
Well Sense
Setting
Professional
Modifier
None
Typical Low
$2,511.89
Median
$2,511.89
Typical High
$3,019.95
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$575.44
Median
$1,148.15
Typical High
$2,570.40
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$575.44
Median
$575.44
Typical High
$575.44
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$229.09
Median
$229.09
Typical High
$229.09
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$933.25
Median
$1,230.27
Typical High
$1,445.44

Where Massachusetts sits

The same service costs 3.7 times more in Alaska than in Georgia. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 8th of 51

$1,148

AK $2,089GA $562

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.