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Tissue-Matching (HLA) Genetic Blood Test

Colorado rates for HCPCS 81377

A genetic blood test that identifies specific tissue-matching markers on white blood cells, known as HLA type. It is most often used to check how well a potential donor's tissue matches a recipient's before an organ or bone marrow transplant, since a closer match lowers the risk of rejection. It may also be used in certain disease-risk or family-relationship testing.

Rates data updated October 2026.

How much does Tissue-Matching (HLA) Genetic Blood Test cost?

$126

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $126 for this service. The price depends on where it is billed: about $56.23 from a physician practice, and about $275 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$56.23$39.81 to $123
FacilityA hospital or hospital-owned outpatient department$275$178 to $331

How much rates vary

Facilitymedian $275 · 10th to 90th $72 to $437Professionalmedian $56 · 10th to 90th $40 to $195
$50$100$200$500facility $275professional $56

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$95.50
Median
$199.53
Typical High
$436.52
Aetna
Setting
Professional
Modifier
None
Typical Low
$70.79
Median
$72.44
Typical High
$100.00
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$281.84
Typical High
$436.52
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$39.81
Typical High
$208.93
Cigna
Setting
Facility
Modifier
None
Typical Low
$54.95
Median
$114.82
Typical High
$302.00
Cigna
Setting
Professional
Modifier
None
Typical Low
$45.71
Median
$56.23
Typical High
$138.04
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$72.44
Median
$91.20
Typical High
$165.96
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$95.50
Median
$134.90
Typical High
$239.88
Select Health
Setting
Facility
Modifier
None
Typical Low
$95.50
Median
$173.78
Typical High
$199.53
Select Health
Setting
Professional
Modifier
None
Typical Low
$66.07
Median
$95.50
Typical High
$141.25
United
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$114.82
Typical High
$114.82
United
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$52.48
Typical High
$70.79
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$35.48
Median
$36.31
Typical High
$50.12
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$14.13
Median
$14.45
Typical High
$19.95

Where Colorado sits

The same service costs 3.5 times more in Kansas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 8th of 51

$126

KS $224AL $63.10

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.