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Analysis Of One Gene

Massachusetts rates for HCPCS 81357

A molecular laboratory test that examines the DNA of a single gene from a patient sample and reports the changes it finds. Results are normally reviewed with a specialist who can explain what they mean for the person tested.

Rates data updated October 2026.

How much does Analysis Of One Gene cost?

$200

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $200 for this service. The price depends on where it is billed: about $195 from a physician practice, and about $234 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$195$115 to $490
FacilityA hospital or hospital-owned outpatient department$234$170 to $347

How much rates vary

Facilitymedian $234 · 10th to 90th $141 to $603Professionalmedian $195 · 10th to 90th $115 to $955
$100$200$500$1K$2K$5Kfacility $234professional $195

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$269.15
Typical High
$602.56
Aetna
Setting
Professional
Modifier
None
Typical Low
$134.90
Median
$134.90
Typical High
$134.90
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$141.25
Median
$218.78
Typical High
$588.84
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$371.54
Typical High
$954.99
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$181.97
Median
$181.97
Typical High
$181.97
Cigna
Setting
Facility
Modifier
None
Typical Low
$123.03
Median
$141.25
Typical High
$338.84
Cigna
Setting
Professional
Modifier
None
Typical Low
$107.15
Median
$208.93
Typical High
$758.58
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$323.59
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$275.42
Median
$275.42
Typical High
$323.59
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$194.98
Typical High
$416.87
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$141.25
Median
$218.78
Typical High
$588.84
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$371.54
Typical High
$954.99
United
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$194.98
Typical High
$234.42
United
Setting
Professional
Modifier
None
Typical Low
$77.62
Median
$114.82
Typical High
$371.54
Well Sense
Setting
Facility
Modifier
None
Typical Low
$169.82
Median
$234.42
Typical High
$346.74
Well Sense
Setting
Professional
Modifier
None
Typical Low
$2,511.89
Median
$2,511.89
Typical High
$3,019.95
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$67.61
Median
$67.61
Typical High
$67.61
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$26.92
Median
$26.92
Typical High
$26.92
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$194.98
Median
$251.19
Typical High
$302.00

Where Massachusetts sits

The same service costs 8.3 times more in Texas than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 20th of 51

$200

TX $955DE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.