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TP53 Gene Test For A Known Family Change

Virginia rates for HCPCS 81353

Checks a blood or saliva sample for one particular change in the TP53 gene that has already been found in a relative. TP53 normally helps stop cells from growing out of control, and inherited changes in it raise the risk of several cancers, sometimes at a young age. Because the exact change being looked for is already known, only that one spot is examined.

Rates data updated October 2026.

How much does TP53 Gene Test For A Known Family Change cost?

$263

Typical negotiated rate. In Virginia, October 2026.

Insurers have agreed to pay about $263 for this service. The price depends on where it is billed: about $229 from a physician practice, and about $380 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$229$174 to $309
FacilityA hospital or hospital-owned outpatient department$380$309 to $724

How much rates vary

Facilitymedian $380 · 10th to 90th $309 to $1,514Professionalmedian $229 · 10th to 90th $129 to $447
$200$500$1K$2K$5K$10Kfacility $380professional $229

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$229.09
Median
$263.03
Typical High
$724.44
Aetna
Setting
Professional
Modifier
None
Typical Low
$229.09
Median
$229.09
Typical High
$263.03
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$309.03
Typical High
$1,513.56
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$169.82
Typical High
$218.78
CareFirst
Setting
Professional
Modifier
None
Typical Low
$223.87
Median
$245.47
Typical High
$288.40
Cigna
Setting
Facility
Modifier
None
Typical Low
$316.23
Median
$537.03
Typical High
$758.58
Cigna
Setting
Professional
Modifier
None
Typical Low
$151.36
Median
$194.98
Typical High
$489.78
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$295.12
Median
$338.84
Typical High
$426.58
Medcost
Setting
Facility
Modifier
None
Typical Low
$398.11
Median
$398.11
Typical High
$398.11
Medcost
Setting
Professional
Modifier
None
Typical Low
$199.53
Median
$199.53
Typical High
$245.47
Sentara
Setting
Facility
Modifier
None
Typical Low
$229.09
Median
$389.05
Typical High
$10,232.93
Sentara
Setting
Professional
Modifier
None
Typical Low
$275.42
Median
$354.81
Typical High
$1,380.38
United
Setting
Facility
Modifier
None
Typical Low
$371.54
Median
$371.54
Typical High
$371.54
United
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$186.21
Typical High
$426.58
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$114.82
Median
$114.82
Typical High
$131.83
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$45.71
Median
$45.71
Typical High
$52.48

Where Virginia sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Virginia· 33rd of 51

$263

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.