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TP53 Gene Test For A Known Family Change

Pennsylvania rates for HCPCS 81353

Checks a blood or saliva sample for one particular change in the TP53 gene that has already been found in a relative. TP53 normally helps stop cells from growing out of control, and inherited changes in it raise the risk of several cancers, sometimes at a young age. Because the exact change being looked for is already known, only that one spot is examined.

Rates data updated July 2026.

How much does TP53 Gene Test For A Known Family Change cost?

$263

Typical negotiated rate. In Pennsylvania, July 2026.

Insurers have agreed to pay about $263 for this service. The price depends on where it is billed: about $251 from a physician practice, and about $589 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$251$195 to $288
FacilityA hospital or hospital-owned outpatient department$589$372 to $851

How much rates vary

Facilitymedian $589 · 10th to 90th $263 to $1,148Professionalmedian $251 · 10th to 90th $162 to $676
$200$500$1K$2Kfacility $589professional $251

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$263.03
Median
$588.84
Typical High
$1,096.48
Aetna
Setting
Professional
Modifier
Global
Typical Low
$165.96
Median
$251.19
Typical High
$1,096.48
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$1,122.02
Median
$1,513.56
Typical High
$8,511.38
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$239.88
Median
$239.88
Typical High
$239.88
Cigna
Setting
Facility
Modifier
Global
Typical Low
$302.00
Median
$501.19
Typical High
$1,047.13
Cigna
Setting
Professional
Modifier
Global
Typical Low
$144.54
Median
$269.15
Typical High
$549.54
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$213.80
Median
$213.80
Typical High
$407.38
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$309.03
Median
$309.03
Typical High
$309.03
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$229.09
Median
$371.54
Typical High
$575.44
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$251.19
Median
$588.84
Typical High
$1,096.48
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$165.96
Median
$251.19
Typical High
$1,096.48
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$338.84
Median
$338.84
Typical High
$758.58
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$338.84
Median
$338.84
Typical High
$338.84
United
Setting
Facility
Modifier
Global
Typical Low
$275.42
Median
$309.03
Typical High
$371.54
United
Setting
Professional
Modifier
Global
Typical Low
$128.82
Median
$186.21
Typical High
$457.09

Where Pennsylvania sits

The same service costs 3.4 times more in Alaska than in Delaware. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 38th of 51

$263

AK $692DE $204

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.