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TP53 Gene Test For A Known Family Change

Maryland rates for HCPCS 81353

Checks a blood or saliva sample for one particular change in the TP53 gene that has already been found in a relative. TP53 normally helps stop cells from growing out of control, and inherited changes in it raise the risk of several cancers, sometimes at a young age. Because the exact change being looked for is already known, only that one spot is examined.

Rates data updated October 2026.

How much does TP53 Gene Test For A Known Family Change cost?

$229

Typical negotiated rate. In Maryland, October 2026.

Insurers have agreed to pay about $229 for this service. Most negotiated rates run $204 to $245.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $229 · 10th to 90th $138 to $309
$200$500professional $229

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Professional
Modifier
None
Typical Low
$229.09
Median
$229.09
Typical High
$251.19
CareFirst
Setting
Professional
Modifier
None
Typical Low
$223.87
Median
$245.47
Typical High
$245.47
Cigna
Setting
Professional
Modifier
None
Typical Low
$162.18
Median
$223.87
Typical High
$891.25
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$309.03
Median
$371.54
Typical High
$457.09
United
Setting
Professional
Modifier
None
Typical Low
$128.82
Median
$154.88
Typical High
$257.04
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$245.47
Median
$245.47
Typical High
$245.47
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$114.82
Median
$114.82
Typical High
$125.89
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$45.71
Median
$45.71
Typical High
$50.12

Where Maryland sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Maryland· 45th of 51

$229

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.