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TP53 Gene Test For A Known Family Change

Iowa rates for HCPCS 81353

Checks a blood or saliva sample for one particular change in the TP53 gene that has already been found in a relative. TP53 normally helps stop cells from growing out of control, and inherited changes in it raise the risk of several cancers, sometimes at a young age. Because the exact change being looked for is already known, only that one spot is examined.

Rates data updated October 2026.

How much does TP53 Gene Test For A Known Family Change cost?

$324

Typical negotiated rate. In Iowa, October 2026.

Insurers have agreed to pay about $324 for this service. The price depends on where it is billed: about $309 from a physician practice, and about $550 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$309$186 to $562
FacilityA hospital or hospital-owned outpatient department$550$347 to $676

How much rates vary

Facilitymedian $550 · 10th to 90th $309 to $832Professionalmedian $309 · 10th to 90th $186 to $1,148
$200$500$1Kfacility $550professional $309

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$239.88
Median
$645.65
Typical High
$870.96
Aetna
Setting
Professional
Modifier
None
Typical Low
$239.88
Median
$239.88
Typical High
$371.54
Cigna
Setting
Professional
Modifier
None
Typical Low
$380.19
Median
$588.84
Typical High
$741.31
Hally Health
Setting
Professional
Modifier
None
Typical Low
$263.03
Median
$457.09
Typical High
$549.54
Medica
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$549.54
Typical High
$794.33
Medica
Setting
Professional
Modifier
None
Typical Low
$186.21
Median
$371.54
Typical High
$1,548.82
Midlands
Setting
Professional
Modifier
None
Typical Low
$380.19
Median
$380.19
Typical High
$407.38
Oscar Health
Setting
Professional
Modifier
None
Typical Low
$309.03
Median
$331.13
Typical High
$660.69
United
Setting
Facility
Modifier
None
Typical Low
$309.03
Median
$309.03
Typical High
$794.33
United
Setting
Professional
Modifier
None
Typical Low
$186.21
Median
$186.21
Typical High
$630.96
Wellmark
Setting
Professional
Modifier
None
Typical Low
$309.03
Median
$309.03
Typical High
$309.03
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$120.23
Median
$120.23
Typical High
$186.21
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$47.86
Median
$47.86
Typical High
$74.13

Where Iowa sits

The same service costs 4.6 times more in Texas than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Iowa· 16th of 51

$324

TX $794AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.