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Cancer-Related Gene Mutation Test

Massachusetts rates for HCPCS 81311

This service is a genetic laboratory test that looks for specific mutations in a gene that is commonly altered in certain cancers. Results can help guide decisions about cancer treatment, including whether a particular targeted therapy is likely to work. The test is run on a tumor tissue sample.

Rates data updated October 2026.

How much does Cancer-Related Gene Mutation Test cost?

$309

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $309 for this service. The price depends on where it is billed: about $295 from a physician practice, and about $427 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$295$178 to $741
FacilityA hospital or hospital-owned outpatient department$427$269 to $692

How much rates vary

Facilitymedian $427 · 10th to 90th $219 to $933Professionalmedian $295 · 10th to 90th $178 to $1,479
$50$100$200$500$1K$2K$5Kfacility $427professional $295

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$208.93
Median
$416.87
Typical High
$933.25
Aetna
Setting
Professional
Modifier
None
Typical Low
$208.93
Median
$208.93
Typical High
$208.93
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$218.78
Median
$338.84
Typical High
$912.01
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$177.83
Median
$562.34
Typical High
$1,479.11
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$34.67
Median
$588.84
Typical High
$851.14
BCBS Massachusetts
Setting
Professional
Modifier
None
Typical Low
$275.42
Median
$275.42
Typical High
$288.40
Cigna
Setting
Facility
Modifier
None
Typical Low
$190.55
Median
$363.08
Typical High
$575.44
Cigna
Setting
Professional
Modifier
None
Typical Low
$162.18
Median
$316.23
Typical High
$1,148.15
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$154.88
Median
$501.19
Typical High
$5,888.44
Fallon Health
Setting
Professional
Modifier
None
Typical Low
$426.58
Median
$426.58
Typical High
$501.19
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$177.83
Median
$295.12
Typical High
$758.58
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$218.78
Median
$338.84
Typical High
$912.01
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$177.83
Median
$562.34
Typical High
$1,479.11
United
Setting
Facility
Modifier
None
Typical Low
$269.15
Median
$295.12
Typical High
$354.81
United
Setting
Professional
Modifier
None
Typical Low
$117.49
Median
$177.83
Typical High
$562.34
Well Sense
Setting
Facility
Modifier
None
Typical Low
$263.03
Median
$363.08
Typical High
$537.03
Well Sense
Setting
Professional
Modifier
None
Typical Low
$2,511.89
Median
$2,511.89
Typical High
$3,019.95
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$104.71
Median
$104.71
Typical High
$104.71
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$41.69
Median
$41.69
Typical High
$41.69
Fallon Health
Setting
Facility
Modifier
QW · Waived lab test
Typical Low
$295.12
Median
$380.19
Typical High
$457.09

Where Massachusetts sits

The same service costs 3.8 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 22nd of 51

$309

AK $661AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.