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Cancer-Related Gene Mutation Test

Illinois rates for HCPCS 81311

This service is a genetic laboratory test that looks for specific mutations in a gene that is commonly altered in certain cancers. Results can help guide decisions about cancer treatment, including whether a particular targeted therapy is likely to work. The test is run on a tumor tissue sample.

Rates data updated October 2026.

How much does Cancer-Related Gene Mutation Test cost?

$229

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $229 for this service. The price depends on where it is billed: about $214 from a physician practice, and about $550 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$214$4.47 to $240
FacilityA hospital or hospital-owned outpatient department$550$398 to $1,047

How much rates vary

Facilitymedian $550 · 10th to 90th $309 to $1,862Professionalmedian $214 · 10th to 90th $3 to $380
$10$100$1Kfacility $550professional $214

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$239.88
Median
$467.74
Typical High
$891.25
Aetna
Setting
Professional
Modifier
None
Typical Low
$234.42
Median
$239.88
Typical High
$269.15
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$354.81
Median
$512.86
Typical High
$3,715.35
BCBS Illinois
Setting
Professional
Modifier
None
Typical Low
$3.47
Median
$204.17
Typical High
$229.09
Cigna
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$616.60
Typical High
$1,230.27
Cigna
Setting
Professional
Modifier
None
Typical Low
$134.90
Median
$338.84
Typical High
$489.78
Hally Health
Setting
Professional
Modifier
None
Typical Low
$309.03
Median
$457.09
Typical High
$891.25
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None
Typical Low
$380.19
Median
$380.19
Typical High
$380.19
United
Setting
Facility
Modifier
None
Typical Low
$295.12
Median
$354.81
Typical High
$371.54
United
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$177.83
Typical High
$295.12
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$120.23
Median
$213.80
Typical High
$446.68
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$48.98
Median
$85.11
Typical High
$177.83
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$120.23
Median
$120.23
Typical High
$131.83
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$48.98
Median
$48.98
Typical High
$53.70

Where Illinois sits

The same service costs 3.8 times more in Alaska than in Alabama. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 42nd of 51

$229

AK $661AL $174

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.