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CYP2C9 Drug Metabolism Gene Test

Virginia rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$148

Typical negotiated rate. In Virginia, October 2026.

Insurers have agreed to pay about $148 for this service. The price depends on where it is billed: about $126 from a physician practice, and about $234 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$126$87.10 to $174
FacilityA hospital or hospital-owned outpatient department$234$174 to $417

How much rates vary

Facilitymedian $234 · 10th to 90th $174 to $871Professionalmedian $126 · 10th to 90th $69 to $257
$50$200$1K$5Kfacility $234professional $126

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$131.83
Median
$147.91
Typical High
$407.38
Aetna
Setting
Professional
Modifier
None
Typical Low
$131.83
Median
$131.83
Typical High
$147.91
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$851.14
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$87.10
Typical High
$120.23
CareFirst
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$141.25
Typical High
$165.96
Cigna
Setting
Facility
Modifier
None
Typical Low
$177.83
Median
$338.84
Typical High
$588.84
Cigna
Setting
Professional
Modifier
None
Typical Low
$87.10
Median
$123.03
Typical High
$295.12
Kaiser Permanente
Setting
Professional
Modifier
None
Typical Low
$165.96
Median
$190.55
Typical High
$245.47
Medcost
Setting
Facility
Modifier
None
Typical Low
$234.42
Median
$234.42
Typical High
$316.23
Medcost
Setting
Professional
Modifier
None
Typical Low
$95.50
Median
$151.36
Typical High
$173.78
Sentara
Setting
Facility
Modifier
None
Typical Low
$158.49
Median
$245.47
Typical High
$10,232.93
Sentara
Setting
Professional
Modifier
None
Typical Low
$158.49
Median
$218.78
Typical High
$812.83
United
Setting
Facility
Modifier
None
Typical Low
$208.93
Median
$208.93
Typical High
$208.93
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$245.47
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$66.07
Median
$66.07
Typical High
$74.13
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$26.30
Median
$26.30
Typical High
$29.51

Where Virginia sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Virginia· 37th of 51

$148

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.