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CYP2C9 Drug Metabolism Gene Test

South Carolina rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$174

Typical negotiated rate. In South Carolina, October 2026.

Insurers have agreed to pay about $174 for this service. The price depends on where it is billed: about $174 from a physician practice, and about $363 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$174$135 to $204
FacilityA hospital or hospital-owned outpatient department$363$182 to $794

How much rates vary

Facilitymedian $363 · 10th to 90th $135 to $1,072Professionalmedian $174 · 10th to 90th $87 to $209
$100$200$500$1Kfacility $363professional $174

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$134.90
Typical High
$134.90
Aetna
Setting
Professional
Modifier
None
Typical Low
$134.90
Median
$134.90
Typical High
$141.25
BCBS South Carolina
Setting
Facility
Modifier
None
Typical Low
$933.25
Median
$933.25
Typical High
$977.24
BCBS South Carolina
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$204.17
Typical High
$245.47
Cigna
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$446.68
Typical High
$1,071.52
Cigna
Setting
Professional
Modifier
None
Typical Low
$79.43
Median
$81.28
Typical High
$181.97
Medcost
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$162.18
Typical High
$501.19
Medcost
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$245.47
United
Setting
Facility
Modifier
None
Typical Low
$158.49
Median
$158.49
Typical High
$208.93
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$173.78
3 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$67.61
Median
$67.61
Typical High
$69.18
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$27.54
Median
$27.54
Typical High
$28.18
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$87.10
Median
$87.10
Typical High
$141.25

Where South Carolina sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

South Carolina· 23rd of 51

$174

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.