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CYP2C9 Drug Metabolism Gene Test

Pennsylvania rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated July 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$148

Typical negotiated rate. In Pennsylvania, July 2026.

Insurers have agreed to pay about $148 for this service. The price depends on where it is billed: about $141 from a physician practice, and about $309 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$141$135 to $166
FacilityA hospital or hospital-owned outpatient department$309$209 to $437

How much rates vary

Facilitymedian $309 · 10th to 90th $148 to $603Professionalmedian $141 · 10th to 90th $95 to $417
$100$200$500$1Kfacility $309professional $141

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$147.91
Median
$338.84
Typical High
$616.60
Aetna
Setting
Professional
Modifier
Global
Typical Low
$104.71
Median
$141.25
Typical High
$616.60
Capital Blue Cross
Setting
Facility
Modifier
Global
Typical Low
$5,011.87
Median
$8,511.38
Typical High
$77,624.71
Capital Blue Cross
Setting
Professional
Modifier
Global
Typical Low
$134.90
Median
$134.90
Typical High
$134.90
Cigna
Setting
Facility
Modifier
Global
Typical Low
$169.82
Median
$288.40
Typical High
$602.56
Cigna
Setting
Professional
Modifier
Global
Typical Low
$81.28
Median
$169.82
Typical High
$398.11
Emblem Health
Setting
Professional
Modifier
Global
Typical Low
$123.03
Median
$123.03
Typical High
$229.09
Geisinger
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$173.78
Geisinger
Setting
Professional
Modifier
Global
Typical Low
$169.82
Median
$269.15
Typical High
$436.52
Martin's Point
Setting
Facility
Modifier
Global
Typical Low
$141.25
Median
$338.84
Typical High
$602.56
Martin's Point
Setting
Professional
Modifier
Global
Typical Low
$104.71
Median
$144.54
Typical High
$616.60
UPMC Health Plan
Setting
Facility
Modifier
Global
Typical Low
$194.98
Median
$302.00
Typical High
$436.52
UPMC Health Plan
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$177.83
Typical High
$194.98
United
Setting
Facility
Modifier
Global
Typical Low
$158.49
Median
$173.78
Typical High
$208.93
United
Setting
Professional
Modifier
Global
Typical Low
$74.13
Median
$104.71
Typical High
$245.47

Where Pennsylvania sits

The same service costs 3.0 times more in Alaska than in Maryland. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 40th of 51

$148

AK $389MD $132

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.