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CYP2C9 Drug Metabolism Gene Test

Pennsylvania rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$141

Typical negotiated rate. In Pennsylvania, October 2026.

Insurers have agreed to pay about $141 for this service. The price depends on where it is billed: about $141 from a physician practice, and about $209 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$141$135 to $174
FacilityA hospital or hospital-owned outpatient department$209$174 to $331

How much rates vary

Facilitymedian $209 · 10th to 90th $141 to $525Professionalmedian $141 · 10th to 90th $95 to $263
$100$500$2K$10K$50Kfacility $209professional $141

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$141.25
Median
$147.91
Typical High
$512.86
Aetna
Setting
Professional
Modifier
None
Typical Low
$138.04
Median
$141.25
Typical High
$147.91
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$69.18
Median
$70.79
Typical High
$74.13
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$27.54
Median
$28.18
Typical High
$29.51
Capital Blue Cross
Setting
Facility
Modifier
None
Typical Low
$4,265.80
Median
$5,011.87
Typical High
$79,432.82
Capital Blue Cross
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$134.90
Typical High
$426.58
Cigna
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$288.40
Typical High
$524.81
Cigna
Setting
Professional
Modifier
None
Typical Low
$83.18
Median
$186.21
Typical High
$269.15
Emblem Health
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$229.09
Typical High
$229.09
Geisinger
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$173.78
Geisinger
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$263.03
Typical High
$436.52
Martin's Point
Setting
Facility
Modifier
None
Typical Low
$141.25
Median
$141.25
Typical High
$602.56
Martin's Point
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$141.25
Typical High
$147.91
Martin's Point
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$70.79
Median
$70.79
Typical High
$74.13
Martin's Point
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$28.18
Median
$28.18
Typical High
$29.51
UPMC Health Plan
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$194.98
Typical High
$436.52
UPMC Health Plan
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$194.98
Typical High
$194.98
United
Setting
Facility
Modifier
None
Typical Low
$158.49
Median
$173.78
Typical High
$208.93
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$208.93

Where Pennsylvania sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 41st of 51

$141

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.