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CYP2C9 Drug Metabolism Gene Test

New York rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$155

Typical negotiated rate. In New York, October 2026.

Insurers have agreed to pay about $155 for this service. The price depends on where it is billed: about $148 from a physician practice, and about $174 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$148$95.50 to $224
FacilityA hospital or hospital-owned outpatient department$174$107 to $372

How much rates vary

Facilitymedian $174 · 10th to 90th $107 to $447Professionalmedian $148 · 10th to 90th $79 to $363
$20$50$100$200$500$1Kfacility $174professional $148

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$95.50
Median
$147.91
Typical High
$537.03
Aetna
Setting
Professional
Modifier
None
Typical Low
$95.50
Median
$95.50
Typical High
$154.88
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$457.09
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$245.47
Typical High
$426.58
CDPHP
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$173.78
Cigna
Setting
Facility
Modifier
None
Typical Low
$169.82
Median
$371.54
Typical High
$501.19
Cigna
Setting
Professional
Modifier
None
Typical Low
$107.15
Median
$213.80
Typical High
$851.14
Emblem Health
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$288.40
Typical High
$478.63
Emblem Health
Setting
Professional
Modifier
None
Typical Low
$107.15
Median
$147.91
Typical High
$234.42
Excellus BCBS
Setting
Facility
Modifier
None
Typical Low
$107.15
Median
$107.15
Typical High
$107.15
Excellus BCBS
Setting
Professional
Modifier
None
Typical Low
$112.20
Median
$165.96
Typical High
$199.53
MVP Health Care
Setting
Facility
Modifier
None
Typical Low
$13.80
Median
$257.04
Typical High
$346.74
MVP Health Care
Setting
Professional
Modifier
None
Typical Low
$95.50
Median
$95.50
Typical High
$363.08
United
Setting
Facility
Modifier
None
Typical Low
$158.49
Median
$173.78
Typical High
$218.78
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$87.10
Typical High
$263.03
Univera
Setting
Facility
Modifier
None
Typical Low
$107.15
Median
$107.15
Typical High
$186.21
Univera
Setting
Professional
Modifier
None
Typical Low
$107.15
Median
$165.96
Typical High
$194.98
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$47.86
Median
$47.86
Typical High
$77.62
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$19.05
Median
$19.05
Typical High
$30.90

Where New York sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

New York· 35th of 51

$155

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.