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CYP2C9 Drug Metabolism Gene Test

Nebraska rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$115

Typical negotiated rate. In Nebraska, October 2026.

Insurers have agreed to pay about $115 for this service. The price depends on where it is billed: about $105 from a physician practice, and about $417 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$105$105 to $331
FacilityA hospital or hospital-owned outpatient department$417$251 to $501

How much rates vary

Facilitymedian $417 · 10th to 90th $105 to $851Professionalmedian $105 · 10th to 90th $100 to $871
$100$200$500$1Kfacility $417professional $105

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$114.82
Median
$416.87
Typical High
$870.96
Aetna
Setting
Professional
Modifier
None
Typical Low
$114.82
Median
$114.82
Typical High
$416.87
BCBS Nebraska
Setting
Facility
Modifier
None
Typical Low
$251.19
Median
$446.68
Typical High
$933.25
Cigna
Setting
Professional
Modifier
None
Typical Low
$323.59
Median
$331.13
Typical High
$416.87
Medica
Setting
Facility
Modifier
None
Typical Low
$63.10
Median
$218.78
Typical High
$831.76
Medica
Setting
Professional
Modifier
None
Typical Low
$104.71
Median
$104.71
Typical High
$870.96
Midlands
Setting
Professional
Modifier
None
Typical Low
$323.59
Median
$323.59
Typical High
$323.59
Midlands
Setting
Professional
Modifier
None
Typical Low
$323.59
Median
$323.59
Typical High
$323.59
United
Setting
Facility
Modifier
None
Typical Low
$63.10
Median
$74.13
Typical High
$104.71
United
Setting
Professional
Modifier
None
Typical Low
$100.00
Median
$104.71
Typical High
$524.81

Where Nebraska sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Nebraska· 51st of 51

$115

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.