go back

CYP2C9 Drug Metabolism Gene Test

North Carolina rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated July 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$148

Typical negotiated rate. In North Carolina, July 2026.

Insurers have agreed to pay about $148 for this service. The price depends on where it is billed: about $141 from a physician practice, and about $155 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$141$135 to $174
FacilityA hospital or hospital-owned outpatient department$155$141 to $269

How much rates vary

Facilitymedian $155 · 10th to 90th $132 to $589Professionalmedian $141 · 10th to 90th $87 to $229
$100$200$500facility $155professional $141

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$109.65
Median
$154.88
Typical High
$588.84
Aetna
Setting
Professional
Modifier
Global
Typical Low
$117.49
Median
$141.25
Typical High
$229.09
BCBS
Setting
Facility
Modifier
Global
Typical Low
$295.12
Median
$389.05
Typical High
$457.09
BCBS
Setting
Professional
Modifier
Global
Typical Low
$79.43
Median
$158.49
Typical High
$281.84
Cigna
Setting
Facility
Modifier
Global
Typical Low
$120.23
Median
$380.19
Typical High
$794.33
Cigna
Setting
Professional
Modifier
Global
Typical Low
$81.28
Median
$83.18
Typical High
$234.42
Medcost
Setting
Facility
Modifier
Global
Typical Low
$141.25
Median
$158.49
Typical High
$269.15
Medcost
Setting
Professional
Modifier
Global
Typical Low
$154.88
Median
$154.88
Typical High
$154.88
United
Setting
Facility
Modifier
Global
Typical Low
$104.71
Median
$204.17
Typical High
$229.09
United
Setting
Professional
Modifier
Global
Typical Low
$74.13
Median
$104.71
Typical High
$181.97
Wellcare
Setting
Facility
Modifier
Global
Typical Low
$831.76
Median
$831.76
Typical High
$831.76
Wellcare
Setting
Professional
Modifier
Global
Typical Low
$870.96
Median
$870.96
Typical High
$1,318.26

Where North Carolina sits

The same service costs 3.0 times more in Alaska than in Maryland. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 41st of 51

$148

AK $389MD $132

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.