go back

CYP2C9 Drug Metabolism Gene Test

Missouri rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$166

Typical negotiated rate. In Missouri, October 2026.

Insurers have agreed to pay about $166 for this service. The price depends on where it is billed: about $151 from a physician practice, and about $302 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$151$74.13 to $240
FacilityA hospital or hospital-owned outpatient department$302$182 to $603

How much rates vary

Facilitymedian $302 · 10th to 90th $158 to $832Professionalmedian $151 · 10th to 90th $72 to $447
$20$50$100$200$500$1Kfacility $302professional $151

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$147.91
Median
$223.87
Typical High
$323.59
Aetna
Setting
Professional
Modifier
None
Typical Low
$147.91
Median
$151.36
Typical High
$186.21
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$812.83
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$72.44
Median
$147.91
Typical High
$316.23
BCBS
Setting
Professional
Modifier
None
Typical Low
$123.03
Median
$173.78
Typical High
$331.13
Cigna
Setting
Facility
Modifier
None
Typical Low
$141.25
Median
$389.05
Typical High
$724.44
Cigna
Setting
Professional
Modifier
None
Typical Low
$79.43
Median
$194.98
Typical High
$251.19
Medica
Setting
Facility
Modifier
None
Typical Low
$158.49
Median
$302.00
Typical High
$831.76
Medica
Setting
Professional
Modifier
None
Typical Low
$87.10
Median
$173.78
Typical High
$870.96
United
Setting
Facility
Modifier
None
Typical Low
$158.49
Median
$158.49
Typical High
$158.49
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$234.42
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$74.13
Median
$75.86
Typical High
$100.00
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$29.51
Median
$30.20
Typical High
$39.81

Where Missouri sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Missouri· 28th of 51

$166

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.