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CYP2C9 Drug Metabolism Gene Test

Minnesota rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$174

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $174 for this service. The price depends on where it is billed: about $174 from a physician practice, and about $174 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$174$148 to $214
FacilityA hospital or hospital-owned outpatient department$174$166 to $427

How much rates vary

Facilitymedian $174 · 10th to 90th $166 to $676Professionalmedian $174 · 10th to 90th $105 to $347
$100$200$500$1Kfacility $174professional $174

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$165.96
Median
$165.96
Typical High
$165.96
Aetna
Setting
Professional
Modifier
None
Typical Low
$165.96
Median
$165.96
Typical High
$165.96
BCBS
Setting
Facility
Modifier
None
Typical Low
$165.96
Median
$173.78
Typical High
$426.58
BCBS
Setting
Professional
Modifier
None
Typical Low
$141.25
Median
$158.49
Typical High
$173.78
Cigna
Setting
Facility
Modifier
None
Typical Low
$346.74
Median
$562.34
Typical High
$1,621.81
Cigna
Setting
Professional
Modifier
None
Typical Low
$204.17
Median
$229.09
Typical High
$338.84
Health Partners
Setting
Facility
Modifier
None
Typical Low
$331.13
Median
$537.03
Typical High
$1,288.25
Health Partners
Setting
Professional
Modifier
None
Typical Low
$199.53
Median
$199.53
Typical High
$331.13
Medica
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$275.42
Typical High
$363.08
Medica
Setting
Professional
Modifier
None
Typical Low
$89.13
Median
$181.97
Typical High
$870.96
United
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$173.78
Typical High
$208.93
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$141.25
Typical High
$407.38
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$81.28
Median
$81.28
Typical High
$81.28
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$33.11
Median
$33.11
Typical High
$33.11
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$81.28
Median
$81.28
Typical High
$83.18
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$33.11
Median
$33.11
Typical High
$33.88

Where Minnesota sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 27th of 51

$174

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.