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CYP2C9 Drug Metabolism Gene Test

Michigan rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$166

Typical negotiated rate. In Michigan, October 2026.

Insurers have agreed to pay about $166 for this service. The price depends on where it is billed: about $166 from a physician practice, and about $166 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 7 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$166$132 to $174
FacilityA hospital or hospital-owned outpatient department$166$166 to $234

How much rates vary

Facilitymedian $166 · 10th to 90th $132 to $339Professionalmedian $166 · 10th to 90th $105 to $209
$10$20$50$100$200$500facility $166professional $166

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$165.96
Median
$165.96
Typical High
$257.04
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$83.18
Median
$83.18
Typical High
$128.82
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$33.11
Median
$33.11
Typical High
$51.29
Aetna
Setting
Professional
Modifier
None
Typical Low
$158.49
Median
$169.82
Typical High
$177.83
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$79.43
Median
$85.11
Typical High
$89.13
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$31.62
Median
$33.88
Typical High
$35.48
BCBS Michigan
Setting
Facility
Modifier
None
Typical Low
$131.83
Median
$194.98
Typical High
$338.84
BCBS Michigan
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$131.83
Typical High
$131.83
CareSource
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$190.55
Typical High
$234.42
Cigna
Setting
Professional
Modifier
None
Typical Low
$79.43
Median
$97.72
Typical High
$239.88
Health Alliance Plan
Setting
Facility
Modifier
None
Typical Low
$165.96
Median
$165.96
Typical High
$478.63
Health Alliance Plan
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$83.18
Median
$83.18
Typical High
$128.82
Health Alliance Plan
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$33.11
Median
$33.11
Typical High
$51.29
Health Alliance Plan
Setting
Professional
Modifier
None
Typical Low
$144.54
Median
$165.96
Typical High
$218.78
Health Alliance Plan
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$83.18
Median
$83.18
Typical High
$83.18
Health Alliance Plan
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$33.11
Median
$33.11
Typical High
$33.11
Priority Health
Setting
Professional
Modifier
None
Typical Low
$79.43
Median
$97.72
Typical High
$239.88
United
Setting
Facility
Modifier
None
Typical Low
$104.71
Median
$158.49
Typical High
$208.93
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$173.78

Where Michigan sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Michigan· 28th of 51

$166

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.