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CYP2C9 Drug Metabolism Gene Test

Massachusetts rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated July 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$174

Typical negotiated rate. In Massachusetts, July 2026.

Insurers have agreed to pay about $174 for this service. The price depends on where it is billed: about $174 from a physician practice, and about $347 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$174$155 to $174
FacilityA hospital or hospital-owned outpatient department$347$240 to $490

How much rates vary

Facilitymedian $347 · 10th to 90th $129 to $562Professionalmedian $174 · 10th to 90th $105 to $437
$100$200$500$1K$2Kfacility $347professional $174

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$123.03
Median
$338.84
Typical High
$562.34
Aetna
Setting
Professional
Modifier
Global
Typical Low
$95.50
Median
$141.25
Typical High
$524.81
AllWays Health Partners
Setting
Facility
Modifier
Global
Typical Low
$128.82
Median
$199.53
Typical High
$575.44
AllWays Health Partners
Setting
Professional
Modifier
Global
Typical Low
$104.71
Median
$173.78
Typical High
$588.84
BCBS
Setting
Facility
Modifier
Global
Typical Low
$275.42
Median
$346.74
Typical High
$501.19
BCBS
Setting
Professional
Modifier
Global
Typical Low
$165.96
Median
$165.96
Typical High
$169.82
Cigna
Setting
Facility
Modifier
Global
Typical Low
$114.82
Median
$213.80
Typical High
$338.84
Cigna
Setting
Professional
Modifier
Global
Typical Low
$95.50
Median
$186.21
Typical High
$457.09
Fallon Health
Setting
Facility
Modifier
Global
Typical Low
$83.18
Median
$3,630.78
Typical High
$9,772.37
Fallon Health
Setting
Professional
Modifier
Global
Typical Low
$131.83
Median
$251.19
Typical High
$295.12
Harvard Pilgrim
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$316.23
Mass General Brigham
Setting
Facility
Modifier
Global
Typical Low
$128.82
Median
$199.53
Typical High
$575.44
Mass General Brigham
Setting
Professional
Modifier
Global
Typical Low
$104.71
Median
$173.78
Typical High
$588.84
United
Setting
Facility
Modifier
Global
Typical Low
$104.71
Median
$173.78
Typical High
$208.93
United
Setting
Professional
Modifier
Global
Typical Low
$104.71
Median
$173.78
Typical High
$389.05

Where Massachusetts sits

The same service costs 3.0 times more in Alaska than in Maryland. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 24th of 51

$174

AK $389MD $132

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.