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CYP2C9 Drug Metabolism Gene Test

Kentucky rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated July 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$138

Typical negotiated rate. In Kentucky, July 2026.

Insurers have agreed to pay about $138 for this service. The price depends on where it is billed: about $117 from a physician practice, and about $174 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$117$58.88 to $148
FacilityA hospital or hospital-owned outpatient department$174$145 to $263

How much rates vary

Facilitymedian $174 · 10th to 90th $145 to $417Professionalmedian $117 · 10th to 90th $59 to $229
$50$100$200$500facility $174professional $117

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$144.54
Median
$144.54
Typical High
$416.87
Aetna
Setting
Professional
Modifier
Global
Typical Low
$123.03
Median
$141.25
Typical High
$208.93
Anthem BCBS
Setting
Facility
Modifier
Global
Typical Low
$109.65
Median
$173.78
Typical High
$181.97
Anthem BCBS
Setting
Professional
Modifier
Global
Typical Low
$58.88
Median
$58.88
Typical High
$69.18
CareSource
Setting
Facility
Modifier
Global
Typical Low
$208.93
Median
$245.47
Typical High
$331.13
CareSource
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$229.09
Typical High
$281.84
Cigna
Setting
Facility
Modifier
Global
Typical Low
$134.90
Median
$309.03
Typical High
$371.54
Cigna
Setting
Professional
Modifier
Global
Typical Low
$81.28
Median
$851.14
Typical High
$851.14
United
Setting
Facility
Modifier
Global
Typical Low
$97.72
Median
$173.78
Typical High
$446.68
United
Setting
Professional
Modifier
Global
Typical Low
$74.13
Median
$104.71
Typical High
$173.78

Where Kentucky sits

The same service costs 3.0 times more in Alaska than in Maryland. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Kentucky· 49th of 51

$138

AK $389MD $132

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.