go back

CYP2C9 Drug Metabolism Gene Test

Kentucky rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$141

Typical negotiated rate. In Kentucky, October 2026.

Insurers have agreed to pay about $141 for this service. The price depends on where it is billed: about $112 from a physician practice, and about $158 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$112$58.88 to $191
FacilityA hospital or hospital-owned outpatient department$158$148 to $234

How much rates vary

Facilitymedian $158 · 10th to 90th $135 to $309Professionalmedian $112 · 10th to 90th $59 to $603
$50$100$200$500facility $158professional $112

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$141.25
Median
$147.91
Typical High
$154.88
Aetna
Setting
Professional
Modifier
None
Typical Low
$131.83
Median
$141.25
Typical High
$173.78
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$109.65
Median
$173.78
Typical High
$181.97
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$44.67
Median
$58.88
Typical High
$173.78
CareSource
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$234.42
Typical High
$245.47
CareSource
Setting
Professional
Modifier
None
Typical Low
$173.78
Median
$229.09
Typical High
$288.40
Cigna
Setting
Facility
Modifier
None
Typical Low
$134.90
Median
$309.03
Typical High
$416.87
Cigna
Setting
Professional
Modifier
None
Typical Low
$125.89
Median
$851.14
Typical High
$851.14
United
Setting
Professional
Modifier
None
Typical Low
$75.86
Median
$104.71
Typical High
$281.84
2 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$66.07
Median
$70.79
Typical High
$87.10
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$26.30
Median
$28.18
Typical High
$34.67

Where Kentucky sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Kentucky· 41st of 51

$141

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.