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CYP2C9 Drug Metabolism Gene Test

Illinois rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated July 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$145

Typical negotiated rate. In Illinois, July 2026.

Insurers have agreed to pay about $145 for this service. The price depends on where it is billed: about $135 from a physician practice, and about $275 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$135$95.50 to $155
FacilityA hospital or hospital-owned outpatient department$275$178 to $355

How much rates vary

Facilitymedian $275 · 10th to 90th $145 to $479Professionalmedian $135 · 10th to 90th $3 to $302
$5$20$100$500$2Kfacility $275professional $135

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$144.54
Median
$275.42
Typical High
$354.81
Aetna
Setting
Professional
Modifier
Global
Typical Low
$128.82
Median
$147.91
Typical High
$323.59
BCBS
Setting
Facility
Modifier
Global
Typical Low
$213.80
Median
$616.60
Typical High
$2,187.76
BCBS
Setting
Professional
Modifier
Global
Typical Low
$3.47
Median
$120.23
Typical High
$134.90
Cigna
Setting
Facility
Modifier
Global
Typical Low
$269.15
Median
$371.54
Typical High
$812.83
Cigna
Setting
Professional
Modifier
Global
Typical Low
$85.11
Median
$213.80
Typical High
$295.12
Hally Health
Setting
Professional
Modifier
Global
Typical Low
$181.97
Median
$316.23
Typical High
$575.44
Hally Health
Setting
Facility
Modifier
Global
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
Global
Typical Low
$229.09
Median
$229.09
Typical High
$229.09
United
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$346.74
United
Setting
Professional
Modifier
Global
Typical Low
$74.13
Median
$104.71
Typical High
$173.78

Where Illinois sits

The same service costs 3.0 times more in Alaska than in Maryland. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 45th of 51

$145

AK $389MD $132

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.