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CYP2C9 Drug Metabolism Gene Test

Illinois rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated October 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$135

Typical negotiated rate. In Illinois, October 2026.

Insurers have agreed to pay about $135 for this service. The price depends on where it is billed: about $126 from a physician practice, and about $324 from a hospital or other facility.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$126$4.37 to $141
FacilityA hospital or hospital-owned outpatient department$324$234 to $617

How much rates vary

Facilitymedian $324 · 10th to 90th $195 to $1,122Professionalmedian $126 · 10th to 90th $3 to $214
$5$20$100$500$2Kfacility $324professional $126

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$144.54
Median
$275.42
Typical High
$524.81
Aetna
Setting
Professional
Modifier
None
Typical Low
$107.15
Median
$144.54
Typical High
$158.49
BCBS Illinois
Setting
Facility
Modifier
None
Typical Low
$208.93
Median
$302.00
Typical High
$2,187.76
BCBS Illinois
Setting
Professional
Modifier
None
Typical Low
$3.47
Median
$120.23
Typical High
$134.90
Cigna
Setting
Facility
Modifier
None
Typical Low
$194.98
Median
$363.08
Typical High
$724.44
Cigna
Setting
Professional
Modifier
None
Typical Low
$87.10
Median
$213.80
Typical High
$288.40
Hally Health
Setting
Professional
Modifier
None
Typical Low
$177.83
Median
$263.03
Typical High
$467.74
Hally Health
Setting
Facility
Modifier
None
Typical Low
$100.00
Median
$100.00
Typical High
$100.00
Hally Health
Setting
Professional
Modifier
None
Typical Low
$229.09
Median
$229.09
Typical High
$229.09
United
Setting
Facility
Modifier
None
Typical Low
$173.78
Median
$208.93
Typical High
$218.78
United
Setting
Professional
Modifier
None
Typical Low
$74.13
Median
$104.71
Typical High
$173.78
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$72.44
Median
$125.89
Typical High
$263.03
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$28.84
Median
$51.29
Typical High
$104.71
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$72.44
Median
$72.44
Typical High
$79.43
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$28.84
Median
$28.84
Typical High
$31.62

Where Illinois sits

The same service costs 3.4 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Illinois· 43rd of 51

$135

AK $389NE $115

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.