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CYP2C9 Drug Metabolism Gene Test

Iowa rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated July 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$174

Typical negotiated rate. In Iowa, July 2026.

Insurers have agreed to pay about $174 for this service. The price depends on where it is billed: about $151 from a physician practice, and about $275 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$151$135 to $331
FacilityA hospital or hospital-owned outpatient department$275$174 to $457

How much rates vary

Facilitymedian $275 · 10th to 90th $135 to $501Professionalmedian $151 · 10th to 90th $105 to $1,148
$100$200$500$1Kfacility $275professional $151

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$134.90
Median
$416.87
Typical High
$501.19
Aetna
Setting
Professional
Modifier
Global
Typical Low
$114.82
Median
$151.36
Typical High
$1,148.15
Cigna
Setting
Facility
Modifier
Global
Typical Low
$309.03
Median
$309.03
Typical High
$309.03
Cigna
Setting
Professional
Modifier
Global
Typical Low
$223.87
Median
$331.13
Typical High
$416.87
Hally Health
Setting
Professional
Modifier
Global
Typical Low
$151.36
Median
$288.40
Typical High
$389.05
Medica
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$208.93
Typical High
$446.68
Medica
Setting
Professional
Modifier
Global
Typical Low
$104.71
Median
$208.93
Typical High
$676.08
Midlands
Setting
Professional
Modifier
Global
Typical Low
$213.80
Median
$229.09
Typical High
$229.09
Oscar Health
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$190.55
Typical High
$371.54
United
Setting
Facility
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$398.11
United
Setting
Professional
Modifier
Global
Typical Low
$104.71
Median
$104.71
Typical High
$446.68
Wellmark
Setting
Professional
Modifier
Global
Typical Low
$173.78
Median
$173.78
Typical High
$173.78

Where Iowa sits

The same service costs 3.0 times more in Alaska than in Maryland. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Iowa· 20th of 51

$174

AK $389MD $132

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.