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CYP2C9 Drug Metabolism Gene Test

Florida rates for HCPCS 81227

Examines the CYP2C9 gene, which carries the instructions for a liver enzyme that breaks down a specific set of medicines. The test checks for the common variants and reports whether a person clears those drugs normally or more slowly than usual, which affects the dose they need.

Rates data updated July 2026.

How much does CYP2C9 Drug Metabolism Gene Test cost?

$145

Typical negotiated rate. In Florida, July 2026.

Insurers have agreed to pay about $145 for this service. The price depends on where it is billed: about $126 from a physician practice, and about $324 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 8 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$126$105 to $155
FacilityA hospital or hospital-owned outpatient department$324$158 to $501

How much rates vary

Facilitymedian $324 · 10th to 90th $132 to $708Professionalmedian $126 · 10th to 90th $95 to $200
$5$20$100$500facility $324professional $126

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$131.83
Median
$407.38
Typical High
$870.96
Aetna
Setting
Professional
Modifier
Global
Typical Low
$104.71
Median
$131.83
Typical High
$199.53
Ambetter
Setting
Professional
Modifier
Global
Typical Low
$107.15
Median
$107.15
Typical High
$107.15
AvMed
Setting
Facility
Modifier
Global
Typical Low
$154.88
Median
$173.78
Typical High
$204.17
AvMed
Setting
Professional
Modifier
Global
Typical Low
$14.13
Median
$173.78
Typical High
$173.78
Cigna
Setting
Facility
Modifier
Global
Typical Low
$93.33
Median
$138.04
Typical High
$707.95
Cigna
Setting
Professional
Modifier
Global
Typical Low
$83.18
Median
$134.90
Typical High
$316.23
Florida Blue
Setting
Facility
Modifier
Global
Typical Low
$323.59
Median
$323.59
Typical High
$323.59
Florida Blue
Setting
Professional
Modifier
Global
Typical Low
$51.29
Median
$104.71
Typical High
$134.90
Molina
Setting
Professional
Modifier
Global
Typical Low
$54.95
Median
$60.26
Typical High
$218.78
United
Setting
Facility
Modifier
Global
Typical Low
$74.13
Median
$158.49
Typical High
$218.78
United
Setting
Professional
Modifier
Global
Typical Low
$61.66
Median
$74.13
Typical High
$229.09
Wellpoint
Setting
Professional
Modifier
Global
Typical Low
$50.12
Median
$173.78
Typical High
$173.78

Where Florida sits

The same service costs 3.0 times more in Alaska than in Maryland. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Florida· 44th of 51

$145

AK $389MD $132

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.