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Asparaginase (Rylaze) Injection

North Carolina rates for HCPCS J9021

Injection, asparaginase, recombinant, (Rylaze), 0.1 mg

Rates data updated October 2026.

How much does Rylaze cost?

$58.88per 0.1 mg

Typical negotiated rate. In North Carolina, October 2026.

Insurers have agreed to pay about $58.88 for each 0.1 mg of this drug. The price depends on where it is billed: about $58.88 from a physician practice, and about $83.18 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per 0.1 mg. Enter the amount given to see what insurers have agreed to pay for it.

mg
In a doctor's office or clinic
$58.88
At a hospital outpatient department
$83.18

The same drug, in the same amount, costs 41% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$58.88$58.88 to $61.66
FacilityA hospital or hospital-owned outpatient department$83.18$70.79 to $110

How much rates vary

Facilitymedian $83 · 10th to 90th $48 to $117Professionalmedian $59 · 10th to 90th $56 to $68
$50$100facility $83professional $59

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$47.86
Median
$47.86
Typical High
$70.79
Aetna
Setting
Professional
Modifier
None
Typical Low
$47.86
Median
$47.86
Typical High
$60.26
BCBS North Carolina
Setting
Facility
Modifier
None
Typical Low
$70.79
Median
$107.15
Typical High
$117.49
BCBS North Carolina
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$67.61
Cigna
Setting
Facility
Modifier
None
Typical Low
$83.18
Median
$95.50
Typical High
$123.03
Cigna
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$58.88
Medcost
Setting
Facility
Modifier
None
Typical Low
$47.86
Median
$47.86
Typical High
$69.18
Medcost
Setting
Professional
Modifier
None
Typical Low
$41.69
Median
$41.69
Typical High
$67.61
United
Setting
Professional
Modifier
None
Typical Low
$56.23
Median
$60.26
Typical High
$60.26
1 more rate with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Medcost
Setting
Professional
Modifier
51 · Multiple procedures
Typical Low
$20.89
Median
$20.89
Typical High
$20.89

Where North Carolina sits

Rates are fairly even across states for this service. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 30th of 51

$58.88

AK $72.44LA $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.