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Asparaginase (Rylaze) Injection

Massachusetts rates for HCPCS J9021

Injection, asparaginase, recombinant, (Rylaze), 0.1 mg

Rates data updated October 2026.

How much does Rylaze cost?

$58.88per 0.1 mg

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $58.88 for each 0.1 mg of this drug. The price depends on where it is billed: about $58.88 from a physician practice, and about $75.86 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per 0.1 mg. Enter the amount given to see what insurers have agreed to pay for it.

mg
In a doctor's office or clinic
$58.88
At a hospital outpatient department
$75.86

The same drug, in the same amount, costs 29% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$58.88$56.23 to $61.66
FacilityA hospital or hospital-owned outpatient department$75.86$58.88 to $105

How much rates vary

Facilitymedian $76 · 10th to 90th $56 to $162Professionalmedian $59 · 10th to 90th $56 to $251
$50$100$200facility $76professional $59

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$81.28
Aetna
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$58.88
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$46.77
Median
$64.57
Typical High
$190.55
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$56.23
Median
$60.26
Typical High
$251.19
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$58.88
Median
$67.61
Typical High
$120.23
Cigna
Setting
Facility
Modifier
None
Typical Low
$56.23
Median
$104.71
Typical High
$257.04
Cigna
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$58.88
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$58.88
Median
$75.86
Typical High
$85.11
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$56.23
Median
$58.88
Typical High
$67.61
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$46.77
Median
$64.57
Typical High
$190.55
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$56.23
Median
$60.26
Typical High
$251.19
United
Setting
Facility
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$58.88
United
Setting
Professional
Modifier
None
Typical Low
$56.23
Median
$56.23
Typical High
$60.26
Well Sense
Setting
Facility
Modifier
None
Typical Low
$61.66
Median
$85.11
Typical High
$138.04
Well Sense
Setting
Professional
Modifier
None
Typical Low
$58.88
Median
$58.88
Typical High
$79.43

Where Massachusetts sits

Rates are fairly even across states for this service. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 35th of 51

$58.88

AK $72.44LA $58.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.