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Hyaluronidase Injection, up to 150 units

Massachusetts rates for HCPCS J3470 · Amphadase

Injection, hyaluronidase, up to 150 units

Rates data updated October 2026.

How much does Amphadase (hyaluronidase) cost?

$32.36per 150 units

Typical negotiated rate. In Massachusetts, October 2026.

Insurers have agreed to pay about $32.36 for each 150 units of this drug. The price depends on where it is billed: about $31.62 from a physician practice, and about $41.69 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per 150 units. Enter the amount given to see what insurers have agreed to pay for it.

units
In a doctor's office or clinic
$31.62
At a hospital outpatient department
$41.69

The same drug, in the same amount, costs 32% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 9 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$31.62$31.62 to $38.90
FacilityA hospital or hospital-owned outpatient department$41.69$31.62 to $63.10

How much rates vary

Facilitymedian $42 · 10th to 90th $32 to $87Professionalmedian $32 · 10th to 90th $32 to $58
$20$50$100facility $42professional $32

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$31.62
Median
$31.62
Typical High
$54.95
Aetna
Setting
Professional
Modifier
None
Typical Low
$31.62
Median
$31.62
Typical High
$40.74
AllWays Health Partners
Setting
Facility
Modifier
None
Typical Low
$16.22
Median
$31.62
Typical High
$104.71
AllWays Health Partners
Setting
Professional
Modifier
None
Typical Low
$31.62
Median
$31.62
Typical High
$57.54
BCBS Massachusetts
Setting
Facility
Modifier
None
Typical Low
$31.62
Median
$36.31
Typical High
$66.07
Cigna
Setting
Facility
Modifier
None
Typical Low
$40.74
Median
$66.07
Typical High
$138.04
Cigna
Setting
Professional
Modifier
None
Typical Low
$31.62
Median
$31.62
Typical High
$70.79
Fallon Health
Setting
Facility
Modifier
None
Typical Low
$31.62
Median
$43.65
Typical High
$63.10
Harvard Pilgrim
Setting
Professional
Modifier
None
Typical Low
$31.62
Median
$31.62
Typical High
$57.54
Mass General Brigham
Setting
Facility
Modifier
None
Typical Low
$16.22
Median
$31.62
Typical High
$104.71
Mass General Brigham
Setting
Professional
Modifier
None
Typical Low
$31.62
Median
$31.62
Typical High
$57.54
United
Setting
Professional
Modifier
None
Typical Low
$31.62
Median
$31.62
Typical High
$57.54
Well Sense
Setting
Facility
Modifier
None
Typical Low
$34.67
Median
$44.67
Typical High
$74.13
Well Sense
Setting
Professional
Modifier
None
Typical Low
$31.62
Median
$31.62
Typical High
$38.02
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$15.85
Median
$15.85
Typical High
$16.60
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$6.31
Median
$6.31
Typical High
$6.61
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$4.79
Median
$4.79
Typical High
$4.90
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$3.16
Median
$3.16
Typical High
$3.31

Where Massachusetts sits

The same service costs 3.8 times more in Alabama than in Virginia. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Massachusetts· 25th of 51

$32.36

AL $120VA $31.62

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.