How much does Ryplazim (plasminogen) cost?

$40.74per mg

Typical negotiated rate. In West Virginia, July 2026.

Insurers have agreed to pay about $40.74 for each mg of this drug. The price depends on where it is billed: about $40.74 from a physician practice, and about $40.74 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

Amount givenmg

In a doctor's office or clinic: $40.74
At a hospital outpatient department: $40.74

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 3 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed by	Who charges it	Typical	Range
Physician practiceA doctor's office, clinic or independent provider	A doctor's office, clinic or independent provider	$40.74	$40.74 to $40.74
FacilityA hospital or hospital-owned outpatient department	A hospital or hospital-owned outpatient department	$40.74	$40.74 to $47.86

How much rates vary

Facilitymedian $41 · 10th to 90th $41 to $48Professionalmedian $41 · 10th to 90th $40 to $48

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier	Facility/Professional	Modifier	Typical Low	Median	Typical High
Aetna Setting Facility Modifier Global Typical Low $40.74 Median $40.74 Typical High $47.86	Facility	Global	$40.74	$40.74	$47.86
Aetna Setting Professional Modifier Global Typical Low $40.74 Median $40.74 Typical High $47.86	Professional	Global	$40.74	$40.74	$47.86
Cigna Setting Facility Modifier Global Typical Low $40.74 Median $45.71 Typical High $51.29	Facility	Global	$40.74	$45.71	$51.29
Cigna Setting Professional Modifier Global Typical Low $40.74 Median $40.74 Typical High $213.80	Professional	Global	$40.74	$40.74	$213.80
United Setting Facility Modifier Global Typical Low $57.54 Median $57.54 Typical High $57.54	Facility	Global	$57.54	$57.54	$57.54
United Setting Professional Modifier Global Typical Low $38.90 Median $39.81 Typical High $47.86	Professional	Global	$38.90	$39.81	$47.86

Where West Virginia sits

The same service costs 1.9 times more in Colorado than in North Carolina. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

West Virginia· 24th of 51

$40.74

CO $66.07NC $33.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.