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Plasminogen Injection

Pennsylvania rates for HCPCS J2998 · Ryplazim

Injection, plasminogen, human-tvmh, 1 mg

Rates data updated October 2026.

How much does Ryplazim (plasminogen) cost?

$40.74per mg

Typical negotiated rate. In Pennsylvania, October 2026.

Insurers have agreed to pay about $40.74 for each mg of this drug. The price depends on where it is billed: about $40.74 from a physician practice, and about $45.71 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

mg
In a doctor's office or clinic
$40.74
At a hospital outpatient department
$45.71

The same drug, in the same amount, costs 12% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 5 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$40.74$40.74 to $40.74
FacilityA hospital or hospital-owned outpatient department$45.71$39.81 to $77.62

How much rates vary

Facilitymedian $46 · 10th to 90th $37 to $151Professionalmedian $41 · 10th to 90th $40 to $43
$50$100facility $46professional $41

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$61.66
Aetna
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$20.42
Median
$20.42
Typical High
$20.42
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$8.13
Median
$8.13
Typical High
$8.13
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$6.17
Median
$6.17
Typical High
$6.17
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$4.07
Median
$4.07
Typical High
$4.07
Capital Blue Cross
Setting
Facility
Modifier
None
Typical Low
$35.48
Median
$39.81
Typical High
$46.77
Capital Blue Cross
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$39.81
Typical High
$39.81
Cigna
Setting
Facility
Modifier
None
Typical Low
$40.74
Median
$67.61
Typical High
$154.88
Cigna
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
Martin's Point
Setting
Facility
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$61.66
Martin's Point
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
Martin's Point
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$20.42
Median
$20.42
Typical High
$20.42
Martin's Point
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$8.13
Median
$8.13
Typical High
$8.13
Martin's Point
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$6.17
Median
$6.17
Typical High
$6.17
Martin's Point
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$4.07
Median
$4.07
Typical High
$4.07
United
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$39.81
Typical High
$54.95

Where Pennsylvania sits

The same service costs 1.8 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Pennsylvania· 14th of 51

$40.74

AK $64.57NE $36.31

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.