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Plasminogen Injection

North Carolina rates for HCPCS J2998 · Ryplazim

Injection, plasminogen, human-tvmh, 1 mg

Rates data updated July 2026.

How much does Ryplazim (plasminogen) cost?

$33.88per mg

Typical negotiated rate. In North Carolina, July 2026.

Insurers have agreed to pay about $33.88 for each mg of this drug. The price depends on where it is billed: about $30.90 from a physician practice, and about $40.74 from a hospital or other facility. The two figures are alternatives, not parts of one bill.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

mg
In a doctor's office or clinic
$30.90
At a hospital outpatient department
$40.74

The same drug, in the same amount, costs 32% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Where it's billed changes the price

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$30.90$30.90 to $40.74
FacilityA hospital or hospital-owned outpatient department$40.74$32.36 to $45.71

How much rates vary

Facilitymedian $41 · 10th to 90th $31 to $62Professionalmedian $31 · 10th to 90th $31 to $43
$50$100facility $41professional $31

Distribution of negotiated rates across all payers (price axis is log-scale). Each curve is scaled to its own total: facility and professional rates are different services, shown together to compare where they cluster. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
Global
Typical Low
$30.90
Median
$40.74
Typical High
$42.66
Aetna
Setting
Professional
Modifier
Global
Typical Low
$30.90
Median
$30.90
Typical High
$42.66
BCBS
Setting
Facility
Modifier
Global
Typical Low
$33.88
Median
$58.88
Typical High
$67.61
BCBS
Setting
Professional
Modifier
Global
Typical Low
$31.62
Median
$31.62
Typical High
$31.62
Cigna
Setting
Facility
Modifier
Global
Typical Low
$45.71
Median
$61.66
Typical High
$95.50
Cigna
Setting
Professional
Modifier
Global
Typical Low
$40.74
Median
$40.74
Typical High
$47.86
Medcost
Setting
Facility
Modifier
Global
Typical Low
$30.90
Median
$32.36
Typical High
$39.81
United
Setting
Facility
Modifier
Global
Typical Low
$40.74
Median
$63.10
Typical High
$64.57
United
Setting
Professional
Modifier
Global
Typical Low
$39.81
Median
$39.81
Typical High
$51.29
Wellcare
Setting
Facility
Modifier
Global
Typical Low
$190.55
Median
$190.55
Typical High
$190.55

Where North Carolina sits

The same service costs 1.9 times more in Colorado than in North Carolina. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

North Carolina· 51st of 51

$33.88

CO $66.07NC $33.88

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.