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Plasminogen Injection

Minnesota rates for HCPCS J2998 · Ryplazim

Injection, plasminogen, human-tvmh, 1 mg

Rates data updated October 2026.

How much does Ryplazim (plasminogen) cost?

$39.81per mg

Typical negotiated rate. In Minnesota, October 2026.

Insurers have agreed to pay about $39.81 for each mg of this drug. The price depends on where it is billed: about $36.31 from a physician practice, and about $47.86 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

mg
In a doctor's office or clinic
$36.31
At a hospital outpatient department
$47.86

The same drug, in the same amount, costs 32% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$36.31$33.11 to $40.74
FacilityA hospital or hospital-owned outpatient department$47.86$47.86 to $66.07

How much rates vary

Facilitymedian $48 · 10th to 90th $32 to $91Professionalmedian $36 · 10th to 90th $32 to $48
$50$100facility $48professional $36

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$47.86
Median
$47.86
Typical High
$47.86
Aetna
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$47.86
Typical High
$47.86
BCBS Minnesota
Setting
Facility
Modifier
None
Typical Low
$32.36
Median
$50.12
Typical High
$66.07
BCBS Minnesota
Setting
Professional
Modifier
None
Typical Low
$28.84
Median
$33.88
Typical High
$40.74
Cigna
Setting
Facility
Modifier
None
Typical Low
$42.66
Median
$89.13
Typical High
$120.23
Cigna
Setting
Professional
Modifier
None
Typical Low
$33.88
Median
$37.15
Typical High
$42.66
Health Partners
Setting
Facility
Modifier
None
Typical Low
$33.88
Median
$83.18
Typical High
$125.89
Health Partners
Setting
Professional
Modifier
None
Typical Low
$33.11
Median
$33.11
Typical High
$33.11
Medica
Setting
Facility
Modifier
None
Typical Low
$30.20
Median
$30.20
Typical High
$74.13
Medica
Setting
Professional
Modifier
None
Typical Low
$36.31
Median
$36.31
Typical High
$66.07
United
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$39.81
Typical High
$74.13
8 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Facility
Modifier
52 · Reduced service
Typical Low
$23.99
Median
$23.99
Typical High
$23.99
Aetna
Setting
Facility
Modifier
53 · Discontinued
Typical Low
$9.55
Median
$9.55
Typical High
$9.55
Aetna
Setting
Facility
Modifier
55 · Aftercare only
Typical Low
$7.24
Median
$7.24
Typical High
$7.24
Aetna
Setting
Facility
Modifier
56 · Pre-op care only
Typical Low
$4.79
Median
$4.79
Typical High
$4.79
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$20.42
Median
$23.99
Typical High
$23.99
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$8.13
Median
$9.55
Typical High
$9.55
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$6.17
Median
$7.24
Typical High
$7.24
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$4.07
Median
$4.79
Typical High
$4.79

Where Minnesota sits

The same service costs 1.8 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Minnesota· 38th of 51

$39.81

AK $64.57NE $36.31

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.