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Plasminogen Injection

Michigan rates for HCPCS J2998 · Ryplazim

Injection, plasminogen, human-tvmh, 1 mg

Rates data updated October 2026.

How much does Ryplazim (plasminogen) cost?

$42.66per mg

Typical negotiated rate. In Michigan, October 2026.

Insurers have agreed to pay about $42.66 for each mg of this drug. The price depends on where it is billed: about $40.74 from a physician practice, and about $91.20 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

mg
In a doctor's office or clinic
$40.74
At a hospital outpatient department
$91.20

The same drug, in the same amount, costs 124% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$40.74$39.81 to $51.29
FacilityA hospital or hospital-owned outpatient department$91.20$53.70 to $120

How much rates vary

Facilitymedian $91 · 10th to 90th $43 to $148Professionalmedian $41 · 10th to 90th $38 to $60
$50$100$200facility $91professional $41

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$38.02
Median
$107.15
Typical High
$120.23
Aetna
Setting
Professional
Modifier
None
Typical Low
$38.02
Median
$38.02
Typical High
$40.74
BCBS Michigan
Setting
Facility
Modifier
None
Typical Low
$43.65
Median
$85.11
Typical High
$162.18
BCBS Michigan
Setting
Professional
Modifier
None
Typical Low
$38.90
Median
$40.74
Typical High
$44.67
Cigna
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
Health Alliance Plan
Setting
Facility
Modifier
None
Typical Low
$42.66
Median
$107.15
Typical High
$147.91
Health Alliance Plan
Setting
Professional
Modifier
None
Typical Low
$38.02
Median
$51.29
Typical High
$69.18
Priority Health
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
United
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$39.81
Typical High
$53.70
5 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$19.05
Median
$19.05
Typical High
$20.42
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$7.59
Median
$7.59
Typical High
$8.13
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$5.75
Median
$5.75
Typical High
$6.17
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$3.80
Median
$3.80
Typical High
$4.07
BCBS Michigan
Setting
Professional
Modifier
JW · Drug discarded
Typical Low
$36.31
Median
$38.02
Typical High
$39.81

Where Michigan sits

The same service costs 1.8 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Michigan· 7th of 51

$42.66

AK $64.57NE $36.31

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.