How much does Ryplazim (plasminogen) cost?

$43.65per mg

Typical physician fee. In Hawaii, October 2026.

Insurers have agreed to pay about $43.65 for each mg of this drug. Most negotiated rates run $31.62 to $43.65.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

Amount givenmg

In a doctor's office or clinic: $43.65

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

Few insurers publish rates for this combination, so treat this figure as a rough guide.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 3 insurance carriers under federal price transparency rules.

How much rates vary

Professionalmedian $44 · 10th to 90th $32 to $51

Distribution of negotiated rates across all payers (price axis is log-scale). Small sample; interpret with caution. Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier	Facility/Professional	Modifier	Typical Low	Median	Typical High
Cigna Setting Professional Modifier None Typical Low $40.74 Median $40.74 Typical High $40.74	Professional	None	$40.74	$40.74	$40.74
HMSA Setting Professional Modifier None Typical Low $43.65 Median $43.65 Typical High $43.65	Professional	None	$43.65	$43.65	$43.65
United Setting Professional Modifier None Typical Low $31.62 Median $31.62 Typical High $60.26	Professional	None	$31.62	$31.62	$60.26

Where Hawaii sits

The same service costs 1.8 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Hawaii· 6th of 51

$43.65

AK $64.57NE $36.31

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.