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Plasminogen Injection

Florida rates for HCPCS J2998 · Ryplazim

Injection, plasminogen, human-tvmh, 1 mg

Rates data updated October 2026.

How much does Ryplazim (plasminogen) cost?

$45.71per mg

Typical negotiated rate. In Florida, October 2026.

Insurers have agreed to pay about $45.71 for each mg of this drug. The price depends on where it is billed: about $39.81 from a physician practice, and about $70.79 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

mg
In a doctor's office or clinic
$39.81
At a hospital outpatient department
$70.79

The same drug, in the same amount, costs 78% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$39.81$39.81 to $40.74
FacilityA hospital or hospital-owned outpatient department$70.79$70.79 to $70.79

How much rates vary

Facilitymedian $71 · 10th to 90th $62 to $71Professionalmedian $40 · 10th to 90th $38 to $41
$50$100facility $71professional $40

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$38.02
Median
$39.81
Typical High
$41.69
Aetna
Setting
Professional
Modifier
None
Typical Low
$38.02
Median
$39.81
Typical High
$39.81
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$19.05
Median
$19.95
Typical High
$19.95
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$7.59
Median
$7.94
Typical High
$7.94
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$5.75
Median
$6.03
Typical High
$6.03
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$3.80
Median
$3.98
Typical High
$3.98
AvMed
Setting
Professional
Modifier
None
Typical Low
$36.31
Median
$36.31
Typical High
$40.74
Cigna
Setting
Facility
Modifier
None
Typical Low
$45.71
Median
$61.66
Typical High
$83.18
Cigna
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
Florida Blue
Setting
Facility
Modifier
None
Typical Low
$70.79
Median
$70.79
Typical High
$70.79
Florida Blue
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
United
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$39.81
Typical High
$42.66
Wellpoint
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$39.81
Typical High
$39.81

Where Florida sits

The same service costs 1.8 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Florida· 4th of 51

$45.71

AK $64.57NE $36.31

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.