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Plasminogen Injection

Colorado rates for HCPCS J2998 · Ryplazim

Injection, plasminogen, human-tvmh, 1 mg

Rates data updated October 2026.

How much does Ryplazim (plasminogen) cost?

$48.98per mg

Typical negotiated rate. In Colorado, October 2026.

Insurers have agreed to pay about $48.98 for each mg of this drug. The price depends on where it is billed: about $38.02 from a physician practice, and about $66.07 from a hospital or other facility.

Work out the cost of a dose

This drug is priced per mg. Enter the amount given to see what insurers have agreed to pay for it.

mg
In a doctor's office or clinic
$38.02
At a hospital outpatient department
$66.07

The same drug, in the same amount, costs 74% more at a hospital than at a doctor's office.

Drug cost only. Giving the drug, the visit itself and any monitoring are billed on their own codes. We do not publish dosing guidance: use the amount from your own prescription or treatment plan.

These are rates insurers have negotiated with providers, not the amount a patient is billed. What you owe depends on your plan's deductible and coinsurance. Based on rates published by 6 insurance carriers under federal price transparency rules.

Prices by location type

Billed byTypicalRange
Physician practiceA doctor's office, clinic or independent provider$38.02$30.20 to $39.81
FacilityA hospital or hospital-owned outpatient department$66.07$48.98 to $75.86

How much rates vary

Facilitymedian $66 · 10th to 90th $43 to $120Professionalmedian $38 · 10th to 90th $30 to $41
$50$100$200facility $66professional $38

Distribution of negotiated rates across all payers (price axis is log-scale). Need provider-level prices or 24+ months of history? Contact us.

Rates by insurance carrier

Insurance Carrier
Aetna
Setting
Facility
Modifier
None
Typical Low
$38.02
Median
$75.86
Typical High
$162.18
Aetna
Setting
Professional
Modifier
None
Typical Low
$38.02
Median
$38.02
Typical High
$75.86
Anthem BCBS
Setting
Facility
Modifier
None
Typical Low
$42.66
Median
$67.61
Typical High
$112.20
Anthem BCBS
Setting
Professional
Modifier
None
Typical Low
$30.20
Median
$30.20
Typical High
$30.20
Cigna
Setting
Facility
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
Cigna
Setting
Professional
Modifier
None
Typical Low
$40.74
Median
$40.74
Typical High
$40.74
Denver HMP
Setting
Facility
Modifier
None
Typical Low
$38.02
Median
$38.02
Typical High
$54.95
Select Health
Setting
Professional
Modifier
None
Typical Low
$42.66
Median
$42.66
Typical High
$42.66
United
Setting
Professional
Modifier
None
Typical Low
$39.81
Median
$39.81
Typical High
$39.81
4 more rates with less common billing modifiers

A modifier changes what was billed, for example a reduced or repeated service. Each of these modifiers carries under 10% of the published rates for this code. Modifier combinations, and modifiers with fewer than 30 rates for a carrier, are not listed.

Insurance Carrier
Aetna
Setting
Professional
Modifier
52 · Reduced service
Typical Low
$19.05
Median
$19.05
Typical High
$38.02
Aetna
Setting
Professional
Modifier
53 · Discontinued
Typical Low
$7.59
Median
$7.59
Typical High
$15.49
Aetna
Setting
Professional
Modifier
55 · Aftercare only
Typical Low
$5.75
Median
$5.75
Typical High
$11.48
Aetna
Setting
Professional
Modifier
56 · Pre-op care only
Typical Low
$3.80
Median
$3.80
Typical High
$7.59

Where Colorado sits

The same service costs 1.8 times more in Alaska than in Nebraska. Every bar is a state, most expensive first. Touch or drag across it to read any state, then open that state for its carriers and full range.

Colorado· 3rd of 51

$48.98

AK $64.57NE $36.31

Median negotiated rate in each state, from every insurer that publishes one. States where no insurer publishes a rate for this service are not shown.